NL-OMON56803尚未招募不适用
Acute effects of ketone monoester supplementation on brain function in older men with overweight - Ketone monoesters and brain function
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 36
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 65 至 99（—）
入选标准
- •- Men, aged between 60-75 years
- •- BMI between 25-30 kg/m2
- •- Fasting plasma glucose < 7.0 mmol/L
- •- Fasting serum total cholesterol < 8.0 mmol/L
- •- Fasting serum triacylglycerol < 4.5 mmol/L
- •- Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg
- •- Stable body weight (weight gain or loss < 3 kg in the past three months)
- •- Willingness to give up being a blood donor from 8 weeks before the start of
- •the study, during the study and for 4 weeks after completion of the study
- •- No difficult venipuncture as evidenced during the screening visit
排除标准
- •- Left-handedness
- •- Following a low-carbohydrate diet or consuming nutritional ketone supplements
- •- Current smoker, or smoking cessation < 12 months
- •- Diabetic patients
- •- Familial hypercholesterolemia
- •- Abuse of drugs
- •- More than 3 alcoholic consumptions per day
- •- Use of products or dietary supplements known to interfere with the main
- •outcomes as judged by the principal investigators
- •- Use medication to treat blood pressure, lipid or glucose metabolism, or
- •neurological or mental disorders.
- •- Use of an investigational product within another biomedical intervention
- •trial within the previous 1-month
- •- Severe medical conditions that might interfere with the study, such as
- •epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive
- •pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and
- •rheumatoid arthritis
- •- Active cardiovascular disease like congestive heart failure or cardiovascular
- •event, such as an acute myocardial infarction or cerebrovascular accident
- •- Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material
- •in body, metal splinter in eye, claustrophobia).
研究者
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