MedPath

A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)

Phase 3
Completed
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
Drug: Placebo
Registration Number
NCT05321069
Lead Sponsor
Boehringer Ingelheim
Brief Summary

This study is open to adults with a lung disease called Idiopathic Pulmonary Fibrosis (IPF). People can join the study if they are 40 years or older. If they already take nintedanib or pirfenidone for their IPF, they can continue treatment throughout the study. The purpose of this study is to find out whether a medicine called BI 1015550 helps people with IPF.

Participants are put into 3 groups randomly, which means by chance. Participants in 2 groups take different doses of BI 1015550 as tablets twice a day. Participants in the placebo group take placebo tablets twice a day. Placebo tablets look like BI 1015550 tablets but do not contain any medicine.

Participants are in the study for up to two and a half years. During the first year, they visit the study site 10 times. Afterwards, they visit the study site every 3 months. The doctors regularly test participants' lung function. The results of the lung function tests are compared between the groups. The doctors also regularly check participants' health and take note of any unwanted effects.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
1177
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
BI 1015550 high doseBI 1015550-
PlaceboPlacebo-
BI 1015550 low doseBI 1015550-
Primary Outcome Measures
NameTimeMethod
Absolute change from baseline in Forced Vital Capacity (FVC) (mL) at Week 52at baseline, at week 52
Secondary Outcome Measures
NameTimeMethod
Absolute change from baseline in DLCO % predicted at Week 52at baseline, at week 52
Time to absolute decline in Diffusing Capacity (of Lung) for Carbon Monoxide (DLCO) % predicted of >15% from baseline or death over the duration of the trialup to 30 months
Time to the first occurrence of any of the components of the composite endpoint: time to first acute IPF exacerbation, first hospitalization for respiratory cause, or death (whichever occurs first) over the duration of the trialup to 30 months

Key secondary endpoint

Time to hospitalization for respiratory cause or death over the duration of trialup to 30 months
Time to death over the duration of trialup to 30 months
Absolute change from baseline in Living with Pulmonary Fibrosis (L-PF) Symptoms Dyspnea domain score at Week 52at baseline, at week 52

The L-PF is a 49-item questionnaire with two modules: Symptoms (28 items) and Impact (21 items).

The Symptom score has three domain scores: dyspnea, cough, and fatigue, as well as a total symptom score.

Items have response options on a five-option numeric rating score with an anchor of 0 "Not at all" to 4 "Extremely", with higher numbers indicating a greater impairment.

Absolute change from baseline in Living with Pulmonary Fibrosis (L-PF) Symptoms Fatigue domain score at Week 52at baseline, at week 52

The L-PF is a 49-item questionnaire with two modules: Symptoms (28 items) and Impact (21 items).

The Symptom score has three domain scores: dyspnea, cough, and fatigue, as well as a total symptom score.

Items have response options on a five-option numeric rating score with an anchor of 0 "Not at all" to 4 "Extremely", with higher numbers indicating a greater impairment.

Absolute change from baseline in Living with Pulmonary Fibrosis (L-PF) Symptoms Cough domain score at Week 52at baseline, at week 52

The L-PF is a 49-item questionnaire with two modules: Symptoms (28 items) and Impact (21 items).

The Symptom score has three domain scores: dyspnea, cough, and fatigue, as well as a total symptom score.

Items have response options on a five-option numeric rating score with an anchor of 0 "Not at all" to 4 "Extremely", with higher numbers indicating a greater impairment.

Absolute change from baseline in FVC % predicted at Week 52at baseline, at week 52
Time to first acute Idiopathic Pulmonary Fibrosis (IPF) exacerbation or death over the duration of trialup to 30 months
Time to absolute decline in FVC % predicted of >10% from baseline or death over the duration of the trialup to 30 months

Trial Locations

Locations (334)

Columbia University Medical Center-New York Presbyterian Hospital

🇺🇸

New York, New York, United States

Weill Cornell Medicine-New York-59955

🇺🇸

New York, New York, United States

Duke University Medical Center

🇺🇸

Durham, North Carolina, United States

Southeastern Research Center-Winston-Salem-61365

🇺🇸

Winston-Salem, North Carolina, United States

University of Cincinnati

🇺🇸

Cincinnati, Ohio, United States

Lowcountry Lung and Critical Care

🇺🇸

Charleston, South Carolina, United States

Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg

🇩🇪

Heidelberg, Germany

Lungenklinik Hemer

🇩🇪

Hemer, Germany

Lungenfachklinik Immenhausen

🇩🇪

Immenhausen, Germany

Hamamatsu University Hospital

🇯🇵

Shizuoka, Hamamatsu, Japan

Juntendo University Hospital

🇯🇵

Tokyo, Bunkyo-ku, Japan

Toranomon Hospital

🇯🇵

Tokyo, Minato-ku, Japan

Kyorin University Hospital

🇯🇵

Tokyo, Mitaka, Japan

Toho University Omori Medical Center

🇯🇵

Tokyo, Ota-ku, Japan

Tokyo Medical University Hospital

🇯🇵

Tokyo, Shinjuku-ku, Japan

Centro de Prevención y Rehabilitación de Enfermedades Pulmon

🇲🇽

Monterrey, Mexico

Oaxaca Site Management Organization, S.C.

🇲🇽

Oaxaca, Mexico

Zuyderland Medisch Centrum

🇳🇱

Heerlen, Netherlands

St. Antonius ziekenhuis, locatie Nieuwegein

🇳🇱

Nieuwegein, Netherlands

Erasmus Medisch Centrum-ROTTERDAM-50697

🇳🇱

Rotterdam, Netherlands

Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa

🇵🇱

Warsaw, Poland

Hospital del Mar

🇪🇸

Barcelona, Spain

Hospital Vall d'Hebron

🇪🇸

Barcelona, Spain

Brussels - UNIV Saint-Luc

🇧🇪

Bruxelles, Belgium

UNIV UZ Gent

🇧🇪

Gent, Belgium

UZ Leuven

🇧🇪

Leuven, Belgium

Fachkrankenhaus Coswig GmbH

🇩🇪

Coswig, Germany

University of Alabama at Birmingham

🇺🇸

Birmingham, Alabama, United States

Cedars-Sinai Medical Center

🇺🇸

Los Angeles, California, United States

University of Southern California

🇺🇸

Los Angeles, California, United States

University of California Los Angeles

🇺🇸

Los Angeles, California, United States

University of California Davis

🇺🇸

Sacramento, California, United States

National Jewish Health

🇺🇸

Denver, Colorado, United States

Yale University School of Medicine

🇺🇸

New Haven, Connecticut, United States

Christiana Hospital

🇺🇸

Newark, Delaware, United States

Georgetown University

🇺🇸

Washington, District of Columbia, United States

St. Francis Medical Institute

🇺🇸

Clearwater, Florida, United States

University of Florida Health Shands Hospital

🇺🇸

Gainesville, Florida, United States

Piedmont Healthcare-Atlanta-57055

🇺🇸

Atlanta, Georgia, United States

Clinical Research Specialists LLC

🇺🇸

Kissimmee, Florida, United States

Advanced Pulmonary Research Institute

🇺🇸

Loxahatchee Groves, Florida, United States

Destin Pulmonary Critical Care

🇺🇸

Santa Rosa Beach, Florida, United States

Evanston Hospital Pulmonary Clinic

🇺🇸

Evanston, Illinois, United States

University of Kansas Medical Center

🇺🇸

Kansas City, Kansas, United States

Louisville Pulmonary Care

🇺🇸

Louisville, Kentucky, United States

Tulane University Hospital and Clinic

🇺🇸

New Orleans, Louisiana, United States

Massachusetts General Hospital

🇺🇸

Boston, Massachusetts, United States

Brigham and Women's Hospital

🇺🇸

Boston, Massachusetts, United States

St. Elizabeth's Medical Center

🇺🇸

Boston, Massachusetts, United States

Infinity Medical Research

🇺🇸

North Dartmouth, Massachusetts, United States

University of Michigan Health System

🇺🇸

Ann Arbor, Michigan, United States

Beaumont Health

🇺🇸

Royal Oak, Michigan, United States

Minnesota Lung Center and Sleep Institute

🇺🇸

Edina, Minnesota, United States

University of Minnesota

🇺🇸

Minneapolis, Minnesota, United States

Mayo Clinic, Rochester

🇺🇸

Rochester, Minnesota, United States

The Lung Research Center, LLC

🇺🇸

Chesterfield, Missouri, United States

Washington University School of Medicine

🇺🇸

Saint Louis, Missouri, United States

Creighton University

🇺🇸

Omaha, Nebraska, United States

University of Nebraska Medical Center

🇺🇸

Omaha, Nebraska, United States

Renown Regional Medical Center

🇺🇸

Reno, Nevada, United States

Dartmouth-Hitchcock Medical Center

🇺🇸

Lebanon, New Hampshire, United States

Northern Westchester Hospital

🇺🇸

Mount Kisco, New York, United States

Cleveland Clinic

🇺🇸

Cleveland, Ohio, United States

The Ohio State University Wexner Medical Center

🇺🇸

Columbus, Ohio, United States

The Oregon Clinic

🇺🇸

Portland, Oregon, United States

University of Pennsylvania

🇺🇸

Philadelphia, Pennsylvania, United States

Jefferson Health Honickman Center

🇺🇸

Philadelphia, Pennsylvania, United States

Temple University Hospital

🇺🇸

Philadelphia, Pennsylvania, United States

Allegheny General Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Clinical Trials Center of Middle Tennessee, LLC

🇺🇸

Franklin, Tennessee, United States

Vanderbilt University Medical Center - Vanderbilt Lung Institute at 100 Oaks

🇺🇸

Nashville, Tennessee, United States

Premier Pulmonary Critical Care and Sleep Medicine

🇺🇸

Denison, Texas, United States

The University of Texas Health Science Center at Houston

🇺🇸

Houston, Texas, United States

UT Health San Antonio

🇺🇸

San Antonio, Texas, United States

University of Utah Health Sciences Center

🇺🇸

Salt Lake City, Utah, United States

Virginia Mason Medical Center

🇺🇸

Seattle, Washington, United States

University of Wisconsin

🇺🇸

Madison, Wisconsin, United States

Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553

🇦🇷

C.a.b.a, Argentina

CEDIC - Centro de Investigacion Clinica

🇦🇷

Caba, Argentina

Hospital Italiano de Buenos Aires

🇦🇷

Caba, Argentina

Consultorios Médicos del Buen Ayre

🇦🇷

Capital Federal, Argentina

Instituto Ave Pulmo

🇦🇷

Mar del Plata, Argentina

INSARES

🇦🇷

Mendoza, Argentina

Centro Respiratorio de Quilmes

🇦🇷

Quilmes, Argentina

Canberra Hospital

🇦🇺

Canberra, Australian Capital Territory, Australia

Royal Prince Alfred Hospital

🇦🇺

Camperdown, New South Wales, Australia

ULB Hopital Erasme

🇧🇪

Bruxelles, Belgium

Westmead Hospital

🇦🇺

Westmead, New South Wales, Australia

Lung Research Queensland

🇦🇺

Chermside, Queensland, Australia

The Prince Charles Hospital

🇦🇺

Chermside, Queensland, Australia

Mater Hospital Brisbane

🇦🇺

South Brisbane, Queensland, Australia

Princess Alexandra Hospital

🇦🇺

Woolloongabba, Queensland, Australia

Lung Research Victoria

🇦🇺

Footscray, Victoria, Australia

Austin Hospital

🇦🇺

Heidelberg, Victoria, Australia

The Alfred Hospital

🇦🇺

Melbourne, Victoria, Australia

Fiona Stanley Hospital

🇦🇺

Murdoch, Western Australia, Australia

Trialswest

🇦🇺

Spearwood, Western Australia, Australia

LKH Klagenfurt am Woerthersee

🇦🇹

Klagenfurt Am Woerthersee, Austria

Krems University Hospital

🇦🇹

Krems, Austria

Hospital Elisabethinen Linz

🇦🇹

Linz, Austria

LKH Salzburg University Hospital

🇦🇹

Salzburg, Austria

AKH - Medical University of Vienna

🇦🇹

Vienna, Austria

Clinic Floridsdorf

🇦🇹

Vienna, Austria

Klinikum Wels - Grieskirchen GmbH

🇦🇹

Wels, Austria

Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim

🇧🇪

Antwerpen, Belgium

Centre Hospitalier Universitaire de Liège

🇧🇪

Liège, Belgium

Yvoir - UNIV UCL de Mont-Godinne

🇧🇪

Yvoir, Belgium

Serviços Medicos Respirar Sul Fluminense

🇧🇷

Barra Mansa, Brazil

Hospital das Clinicas da Universidade Federal HC-UFMG

🇧🇷

Belo Horizonte,Minas Gerais, Brazil

Edumed - Educacao e Saude SA

🇧🇷

Curitiba, Brazil

CLARE - Clinica de Pneumologia

🇧🇷

Goiania, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre

🇧🇷

Porto Alegre, Brazil

Hospital Alemao Oswaldo Cruz

🇧🇷

Sao Paulo, Brazil

CEMEC - Centro Multidisciplinar de Estudos Clínicos

🇧🇷

São Bernardo do Campo, Brazil

University of Alberta Hospital (University of Alberta)

🇨🇦

Edmonton, Alberta, Canada

Kelowna Respirology & Allergy Research

🇨🇦

Kelowna, British Columbia, Canada

IUCPQ (Laval University)

🇨🇦

Quebec, Canada

Instituto Nacional del Tórax

🇨🇱

Providencia, Santiago De Chile, Chile

Centro de Investigación del Maule

🇨🇱

Talca, Chile

Vancouver General Hospital

🇨🇦

Vancouver, British Columbia, Canada

Dr. Georges-L.-Dumont University Hospital Centre

🇨🇦

Moncton, New Brunswick, Canada

St. Paul's Hospital (Vancouver)

🇨🇦

Vancouver, British Columbia, Canada

QEII Health Sciences Centre

🇨🇦

Halifax, Nova Scotia, Canada

St. Joseph's Healthcare Hamilton

🇨🇦

Hamilton, Ontario, Canada

Dr. Syed Anees Medicine Professional Corporation

🇨🇦

Windsor, Ontario, Canada

Centre Hospitalier de l'Universite de Montreal (CHUM)

🇨🇦

Montreal, Quebec, Canada

McGill University Health Centre (MUHC)

🇨🇦

Montreal, Quebec, Canada

CIC Mauricie Inc.

🇨🇦

Trois-Rivieres, Quebec, Canada

China-Japan Friendship Hospital

🇨🇳

Beijing, China

Peking Union Medical College Hospital

🇨🇳

Beijing, China

Chinese PLA General Hospital

🇨🇳

Beijing, China

The Second Xiangya Hospital Of Central South University

🇨🇳

Changsha, China

Jinhua Municipal Central Hospital

🇨🇳

Jinhua, China

Huadong Hospital affiliated to Fudan University

🇨🇳

Shanghai, China

West China Hospital

🇨🇳

Chengdu, China

First Affiliated Hospital of Guangzhou Medical University

🇨🇳

Guangzhou, China

NanFang Hosptial

🇨🇳

Guangzhou, China

Hangzhou First People's Hospital

🇨🇳

Hangzhou, China

The Second Affiliated Hospital Zhejiang University School of Medicine

🇨🇳

Hangzhou, China

Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine

🇨🇳

Hangzhou, China

Anhui Provincial Hospital

🇨🇳

Hefei, China

The First hospital of Jiaxing

🇨🇳

Jiaxing, China

Nanjing Drum Tower Hospital

🇨🇳

Nanjing, China

The First Affiliated Hospital of Ningbo University

🇨🇳

Ningbo, China

Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH

🇩🇪

Essen, Germany

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

🇨🇳

Shanghai, China

Zhongshan Hospital Affiliated to Fudan University

🇨🇳

Shanghai, China

Shanghai Chest Hospital

🇨🇳

Shanghai, China

Shanghai Pulmonary Hospital

🇨🇳

Shanghai, China

China Shenyang Chest Hospital

🇨🇳

Shenyang, China

Shenzhen People's Hospital

🇨🇳

Shenzhen, China

The University of Hong Kong-Shenzhen Hospital

🇨🇳

Shenzhen, China

Universitätsklinikum Hamburg, Eppendorf

🇩🇪

Hamburg, Germany

People's Hospital of Sichuan Province

🇨🇳

Sichuan, China

The First Affiliated Hospital of Soochow University

🇨🇳

Suzhou, China

Tianjin Medical University General Hospital

🇨🇳

Tianjin, China

Wuhan Union Hospital

🇨🇳

Wuhan, China

Klinikum Region Hannover GmbH

🇩🇪

Hannover, Germany

Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T

🇨🇳

Wuhan, China

Renmin Hospital of Wuhan University

🇨🇳

Wuhan, China

Wuxi People's Hospital

🇨🇳

Wuxi, China

Second Affiliated Hospital of Xi'an JiaoTong University

🇨🇳

Xi'an, China

Affiliated Hospital, Xuzhou Medical college

🇨🇳

Xuzhou, China

Yichang NO.1 People's Hospital

🇨🇳

Yichang, China

University Hospital Dubrava

🇭🇷

Zagreb, Croatia

Aarhus University Hospital

🇩🇰

Aarhus N, Denmark

Herlev and Gentofte Hospital

🇩🇰

Hellerup, Denmark

Odense University Hospital

🇩🇰

Odense, Denmark

North Estonia Medical Centre Foundation, Tallinn

🇪🇪

Tallinn, Estonia

HYKS Keuhkosairauksien tutkimusyksikkö

🇫🇮

Helsinki, Finland

Oulun yliopistollinen keskussairaala

🇫🇮

Oulu, Finland

HOP d'Angers

🇫🇷

Angers, France

HOP Avicenne

🇫🇷

Bobigny, France

HOP de la Cavale Blanche

🇫🇷

Brest, France

HOP Louis Pradel

🇫🇷

Bron, France

Medizinische Hochschule Hannover

🇩🇪

Hannover, Germany

HOP CHU Caen

🇫🇷

Caen, France

HOP François Mitterrand

🇫🇷

Dijon, France

HOP Michallon

🇫🇷

La Tronche, France

HOP Bicêtre

🇫🇷

Le Kremlin-Bicêtre, France

INS Coeur Poumon

🇫🇷

Lille, France

HOP Nord

🇫🇷

Marseille, France

HOP Nord Laennec

🇫🇷

Nantes Cedex 01, France

HOP Pasteur

🇫🇷

Nice, France

HOP Paris Saint-Joseph

🇫🇷

Paris, France

HOP Tenon

🇫🇷

Paris, France

HOP Bichat

🇫🇷

Paris, France

HOP Haut-Lévêque

🇫🇷

Pessac, France

HOP Robert Debré

🇫🇷

Reims, France

HOP Pontchaillou

🇫🇷

Rennes, France

HOP Charles Nicolle

🇫🇷

Rouen, France

HOP Civil

🇫🇷

Strasbourg, France

HOP Foch

🇫🇷

Suresnes, France

HOP Larrey

🇫🇷

Toulouse, France

Klinikum Chemnitz gGmbH

🇩🇪

Chemnitz, Germany

HOP Bretonneau

🇫🇷

Tours, France

Velocity Clinical Research Germany GmbH-Ahrensburg-69816

🇩🇪

Ahrensburg, Germany

CIMS Studienzentrum Bamberg GmbH

🇩🇪

Bamberg, Germany

Vivantes Netzwerk für Gesundheit GmbH

🇩🇪

Berlin, Germany

Universitätsklinikum Bonn AöR

🇩🇪

Bonn, Germany

Klinikum Konstanz

🇩🇪

Konstanz, Germany

Klinikum der Universität München - Campus Großhadern

🇩🇪

München, Germany

Klinikum Nürnberg

🇩🇪

Nürnberg, Germany

Krankenhaus Bethanien gGmbH

🇩🇪

Solingen, Germany

Helios Hanseklinikum Stralsund

🇩🇪

Stralsund, Germany

Robert-Bosch-Krankenhaus GmbH

🇩🇪

Stuttgart, Germany

Universitätsklinikum Tübingen

🇩🇪

Tübingen, Germany

Petrus-Krankenhaus

🇩🇪

Wuppertal, Germany

Hospital of Heraklion (PAGNI)

🇬🇷

Voutes, Greece

University of Debrecen Clinical Centre

🇭🇺

Debrecen, Hungary

Univ. Gen. Hosp. of Ioannina

🇬🇷

Ioannina, Greece

Univ. Gen. Hosp. of Patras

🇬🇷

Patras, Greece

Koranyi National Institute For Pulmonolgy

🇭🇺

Budapest, Hungary

Connolly Hospital Blanchardstown

🇮🇪

Dublin 15, Ireland

A.O.U. Policlinico Vittorio Emanuele

🇮🇹

Catania, Italy

A. O. Universitaria Careggi

🇮🇹

Firenze, Italy

Ospedale Colonnello D Avanzo

🇮🇹

Foggia, Italy

Ospedale G.B. Morgagni

🇮🇹

Forli', Italy

Osp. S. Giuseppe Fatebenefratelli

🇮🇹

Milano, Italy

Azienda Ospedaliera Policlinico di Modena

🇮🇹

Modena, Italy

Azienda Ospedaliera Universitaria di Padova

🇮🇹

Padova, Italy

Pol. Universitario Tor Vergata

🇮🇹

Roma, Italy

Poli Univ A. Gemelli

🇮🇹

Roma, Italy

A.O.U. Senese Policlinico Santa Maria alle Scotte

🇮🇹

Siena, Italy

Ospedali Riuniti di Ancona

🇮🇹

Torrette Di Ancona (Ancona), Italy

Tosei General Hospital

🇯🇵

Aichi, Seto, Japan

Fujita Health University Hospital

🇯🇵

Aichi, Toyoake, Japan

Chiba University Hospital

🇯🇵

Chiba, Chiba, Japan

IUHW Narita Hospital

🇯🇵

Chiba, Narita, Japan

University of Fukui Hospital

🇯🇵

Fukui, Yoshida-gun, Japan

National Hospital Organization Kyushu Medical Center

🇯🇵

Fukuoka, Fukuoka, Japan

Kyushu University Hospital

🇯🇵

Fukuoka, Fukuoka, Japan

Aso Co.,Ltd Iizuka Hospital

🇯🇵

Fukuoka, Iizuka, Japan

Kurume University Hospital

🇯🇵

Fukuoka, Kurume, Japan

Fukushima Medical University Hospital

🇯🇵

Fukushima, Fukushima, Japan

Tsuboi Hospital

🇯🇵

Fukushima, Koriyama, Japan

Hospital General Universitario de Alicante

🇪🇸

Alicante, Spain

Hiroshima Prefectural Hospital

🇯🇵

Hiroshima, Hiroshima, Japan

Sapporo Medical University Hospital

🇯🇵

Hokkaido, Sapporo, Japan

National Hospital Organization Himeji Medical Center

🇯🇵

Hyogo, Himeji, Japan

Kobe City Medical Center General Hospital

🇯🇵

Hyogo, Kobe, Japan

Kobe City Hospital Organization Kobe City Medical Center West Hospital

🇯🇵

Hyogo, Kobe, Japan

Kanagawa Cardiovascular and Respiratory Center

🇯🇵

Kanagawa, Yokohama, Japan

Saiseikai Kumamoto Hospital

🇯🇵

Kumamoto, Kumamoto, Japan

Nagasaki University Hospital

🇯🇵

Nagasaki, Nagasaki, Japan

Kindai University Hospital

🇯🇵

Osaka, Osakasayama, Japan

National Hospital Organization Kinki-Chuo Chest Medical Center

🇯🇵

Osaka, Sakai, Japan

Saitama Red Cross Hospital

🇯🇵

Saitama, Saitama, Japan

Shimane University Hospital

🇯🇵

Shimane, Izumo, Japan

Jichi Medical University Hospital

🇯🇵

Tochigi, Shimotsuke, Japan

Tokushima University Hospital

🇯🇵

Tokushima, Tokushima, Japan

Center Hospital of the National Center for Global Health and Medicine

🇯🇵

Tokyo, Shinjuku-ku, Japan

Wakayama Medical University Hospital

🇯🇵

Wakayama, Wakayama, Japan

The Catholic University of Korea, Bucheon St.Mary's Hospital

🇰🇷

Bucheon, Korea, Republic of

Seoul National University Bundang Hospital

🇰🇷

Seongnam, Korea, Republic of

Kyung Hee University Hospital

🇰🇷

Seoul, Korea, Republic of

Seoul National University Hospital

🇰🇷

Seoul, Korea, Republic of

Severance Hospital

🇰🇷

Seoul, Korea, Republic of

Soonchunhyang University Hospital Seoul

🇰🇷

Seoul, Korea, Republic of

Asan Medical Center

🇰🇷

Seoul, Korea, Republic of

Samsung Medical Center

🇰🇷

Seoul, Korea, Republic of

Hospital Sultan Idris Shah Serdang

🇲🇾

Kajang, Malaysia

Institut Perubatan Respiratori

🇲🇾

Kuala Lumpur, Malaysia

Sarawak General Hospital

🇲🇾

Kuching, Malaysia

Hospital Pulau Pinang-Pulau Pinang-21953

🇲🇾

Pulau Pinang, Malaysia

Centro de Investigacion Integral MEDIVEST S.C

🇲🇽

Chihuahua, Mexico

Soltmed Smo

🇲🇽

Ciudad de Mexico, Mexico

Centro Respiratorio de Mexico

🇲🇽

Ciudad de Mexico, Mexico

Waikato Hospital

🇳🇿

Hamilton, New Zealand

Greenlane Clinical Centre

🇳🇿

One Tree Hill, Auckland, New Zealand

Middlemore Clinical Trials

🇳🇿

Papatoetoe, New Zealand

Tauranga Hospital

🇳🇿

Tauranga South, New Zealand

Haukeland Universitetssykehus

🇳🇴

Bergen, Norway

Akershus Universitetssykehus HF

🇳🇴

Lørenskog, Norway

Oslo Universitetssykehus HF, Rikshospitalet

🇳🇴

Oslo, Norway

University Clinical Center, Gdansk

🇵🇱

Gdansk, Poland

Alergopneuma Medical Center

🇵🇱

Swidnik, Poland

ULS de Coimbra, E.P.E.

🇵🇹

Coimbra, Portugal

USLM, EPE - Hospital Pedro Hispano

🇵🇹

Matosinhos, Portugal

Allianze Pulmonary Research LLC

🇵🇷

Guaynabo, Puerto Rico

National University Hospital-Singapore-42005

🇸🇬

Singapore, Singapore

Singapore General Hospital

🇸🇬

Singapore, Singapore

Tan Tock Seng Hospital

🇸🇬

Singapore, Singapore

Busamed Paardevlei Private Hospital

🇿🇦

Cape Town, South Africa

Melomed Gatesville Hospital

🇿🇦

Cape Town, South Africa

KwaPhila Health Solutions

🇿🇦

Durban, South Africa

Hospital Clínic de Barcelona

🇪🇸

Barcelona, Spain

Hospital de Basurto

🇪🇸

Bilbao, Spain

Hospital Universitario Virgen de la Arrixaca

🇪🇸

El Palmar, Spain

Hospital de Galdakao

🇪🇸

Galdakao, Spain

Hospital Universitari de Girona Doctor Josep Trueta

🇪🇸

Girona, Spain

Hospital Universitario Virgen de las Nieves

🇪🇸

Granada, Spain

Hospital de Bellvitge

🇪🇸

L'Hospitalet de Llobregat, Spain

Hospital Universitario Lucus Augusti

🇪🇸

Lugo, Spain

Hospital La Princesa

🇪🇸

Madrid, Spain

Hospital General Universitario Gregorio Marañón

🇪🇸

Madrid, Spain

Hospital Universitario Infanta Leonor

🇪🇸

Madrid, Spain

Hospital Ramón y Cajal

🇪🇸

Madrid, Spain

Hospital Universitario 12 de Octubre

🇪🇸

Madrid, Spain

Hospital Virgen de la Victoria

🇪🇸

Malaga, Spain

Hospital Central de Asturias

🇪🇸

Oviedo, Spain

Hospital Son Espases

🇪🇸

Palma de Mallorca, Spain

Hospital Quirónsalud Madrid

🇪🇸

Pozuelo de Alarcón, Spain

Hospital Universitario Marqués de Valdecilla

🇪🇸

Santander, Spain

Hospital Clínico de Santiago

🇪🇸

Santiago de Compostela, Spain

Hospital Virgen del Rocío

🇪🇸

Sevilla, Spain

Hospital Nuestra Señora de Valme

🇪🇸

Sevilla, Spain

Hospital General Universitario de Valencia

🇪🇸

Valencia, Spain

Universitetssjukhuset, Linköping

🇸🇪

Linköping, Sweden

Akademiska sjukhuset

🇸🇪

Uppsala, Sweden

University Hospital Basel

🇨🇭

Basel, Switzerland

Chang-Hua Christian Hospital

🇨🇳

Changhua, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

🇨🇳

Kaohsiung, Taiwan

Far Eastern Memorial Hospital

🇨🇳

New Taipei City, Taiwan

Taipei Veterans General Hospital

🇨🇳

Taipei, Taiwan

Kaohsiung Chang Gung Memorial Hospital

🇨🇳

Kaohsiung, Taiwan

Taichung Veterans General Hospital

🇨🇳

Taichung, Taiwan

NCKUH

🇨🇳

Tainan, Taiwan

National Taiwan University Hospital

🇨🇳

Taipei, Taiwan

Siriraj Hospital

🇹🇭

Bangkok Noi, Thailand

Songklanagarind Hospital

🇹🇭

Hat Yai, Thailand

Srinagarind Hospital

🇹🇭

Khon Kaen, Thailand

Central Chest Institute of Thailand

🇹🇭

Muang, Thailand

Maharat Nakhonchiangmai Hospital

🇹🇭

Muang, Thailand

Ramathibodi Hospital

🇹🇭

Ratchatewi, Thailand

Queen Elizabeth Hospital Birmingham

🇬🇧

Birmingham, United Kingdom

Southmead Hospital

🇬🇧

Bristol, United Kingdom

Royal Infirmary of Edinburgh

🇬🇧

Edinburgh, United Kingdom

Royal Devon and Exeter Hospital, Wonford

🇬🇧

Exeter, United Kingdom

Royal Lancaster Infirmary

🇬🇧

Lancaster, United Kingdom

St James's University Hospital

🇬🇧

Leeds, United Kingdom

Royal Brompton Hospital

🇬🇧

London, United Kingdom

Wythenshawe Hospital

🇬🇧

Manchester, United Kingdom

Churchill Hospital

🇬🇧

Oxford, United Kingdom

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