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临床试验/NCT04708873
NCT04708873Unknown不适用

Effect of High Intensity Aerobic & Resistance Interval Training on Body Composition, Visceral Adiposity and Myocardial Function in Overweight and Obese Adults

Foundation University Islamabad2 个研究点 分布在 1 个国家目标入组 52 人开始时间: 2020年11月25日最近更新:
适应症

试验速览

阶段
不适用
入组人数
52
试验地点
2
主要终点
Percentage Body Fat

研究概览

简要总结

The obesity epidemic, predisposing to cardio-metabolic diseases, has increased two-folds over the last decade with a global alarming cost of obesity-associated illnesses, thus representing a grave peril for the survival of public health care systems. It is need of the time to develop evidence-based, time-efficient and cost-effective strategies to prevent and manage obesity. This study would compare the effects of 2 types of exercise regimes providing data on their beneficial effects on body composition and myocardial function along with reducing the central adiposity. This study may also be used as a novel intervention strategy for primary prevention of cardiovascular and metabolic diseases by modification of a major risk factor i.e. obesity in Pakistani population, consequently reducing the burden of morbidity and mortality from cardiometabolic diseases.

详细描述

Obesity is one of the major public health issues of this century. Over the last decade, the prevalence of obesity has increased globally, making it an emerging epidemic and threatening the survival of health care systems. Obesity has long been recognized as the major factor predisposing to cardio-metabolic diseases.The positive role of structured exercise for reducing the mortality and morbidity rates of obese and sedentary adults is well established. But exercise engagement is seen to be quite low in obese adults mainly due to lack of time and non-adherence to exercise training programs. Current trends are now focusing towards another type of exercise regime known as high intensity interval training (HIIT), which is composed of repetitive short to long (< 45 sec to 4 min) bouts of high intensity exercise alternating with rest or recovery periods. Resistance training can also stimulate changes in body composition indices as well as maintain the reduced fat mass after training. Thus resistance exercises are recommended as an adjunct for obesity management by reduction in risk factors. Hence, this study is designed to determine the effects of high intensity interval training in combination with resistance exercises verses moderate intensity continuous training on multiple outcome variables including body composition parameters, visceral adiposity, lipid profile and myocardial function in overweight and obese adult population of Pakistan. Afte r obtaining written informed consent from paricipants, they will be screened using 2020 PAR-Q plus and randomly allocated to one of the 2 groups. A self-structured demographic sheet would be employed for recording demographics and required data including the findings of lab investigations. Then participants will be required to undergo all the physical assessment measures such as anthropometric data, 6 minute walk test, lipid profile, body composition analysis and echocardiography. Physical activity levels and QOL would be assessed by filling IPAQ and SF 36 respectively. Exercise training plans would be performed thrice a week on alternate days for a total duration of 10 weeks. All measurements (anthropometric, cardiac, blood and body composition analyses) would be performed at baseline and later after the 10 weeks intervention period. Exercise intensity will be determined by individualized target heart rate zones using Karvonen formula. Strength training intensity will be determined based on 1-RM. Necessary adjustments to speed/grade and resistance will be made over the course of the intervention to ensure that target heart rate zones are achieved at all times. Apart from the exercise programs, a general similar dietary guidance by a nutritionist would also be provided to both of the groups to avoid unhealthy dietary habits.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Participant)

盲法说明

It will be a single blinded study. Only the participants will be masked.

入排标准

年龄范围
18 Years 至 55 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Individuals categorized as Overweight (BMI 23.0 to 24.9) and Obese-Class I (BMI 25.0 to 29.9).
  • Both males & females willing to participate in the study.
  • Otherwise healthy young adults aged 18-35 and middle-aged adults (36-55 years).
  • No participation in an exercise or PA program during the last 6 months prior to the study.
  • Participants able to complete 6-minute walk test as sub-maximal evaluation test without provoking sign and symptoms.

排除标准

  • Any diagnosed neuromuscular, cardiac, renal, lung, liver disease.
  • Individuals with implantable electrical devices such as pacemakers.
  • Any physical or psychological dysfunction that hinders participation in the study.
  • Individuals already participating in any structured program for weight loss including dietary interventions or usage of nutritional supplements.
  • Individuals unable to complete 6 minute walk test due to any reason (dyspnea, fatigue, chest pain etc).

结局指标

主要结局

Percentage Body Fat

时间窗: 10 weeks

Percentage body fat will be measured using Bioelectrical Impedance Analyzer (Inbody 770) and expressed in forms of percentage (%).

Visceral fat area

时间窗: 10 weeks

Visceral fat area will be measured using Bioelectrical Impedance Analyzer (Inbody 770) and expressed in form of centimeter square.

次要结局

  • Left Ventricular Mass(10 weeks)
  • Left Ventricular Ejection Fraction(10 weeks)
  • Cholesterol/HDL ratio(10 weeks)
  • Fat free mass(10 weeks)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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