The effect of skin care product containing heat-treated probiotic, fructooligosaccharide and galactooligosaccharide on irritation, moisturization, transepidermal water loss, oiliness, skin gloss, skin color, wrinkle, skin microbiome, and satisfaction in volunteers

Phase 1

• Conditions: Healthy men and women, 20- 65 years old; skin cares, heat- treated probiotic, fructooligosaccharide, galactooligosaccharide, irritation, moisturization&#44

• Registration Number: TCTR20200917006
• Lead Sponsor: Innovation and technology assistance program, Thailand Science Park

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-09-17
• Study Completion: 2020-10-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

- No skin diseases, tattoos or wounds appear on the test site
- Not allergic to the ingredients of products after receiving the test product
- No pregnancy or lactation
- No midical history of autoimmune diseases
- No symptoms that have to be hospitalized during the past 6 months
- Good health and normal mental state
- Have consent to participate
- Volunteers who did not participate in other clinical tests in 3 months before
- Have not taken the antibiotic 14 days before the program start

Exclusion Criteria

- Volunteers who need to apply products that affect moisture, oil, and other skin shine at the test site of the project During the experiment, such as cream or body lotion, hand cream and body oil, etc.
- Volunteers taking medication related to chronic diseases or requiring antibiotics for a period of more than 14 days while participating in the project

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Irritation on area of products After applying the product for 0,24 and 48 hours Patch test and Aramo Smart® ,Moisture Content After applying the product for 0,1,2,3,4,5 hours and 4 weeks MoistureMeter SC,Transepidermal Water Loss (TEWL) After applying the product for 0,1,2,3,4,5 hours and 4 weeks VapoMeter,Sebum Secretion After applying the product for 0,1,2,3,4,5 hours and 4 weeks Sebumscale,Skin Gloss After applying the product for 0,1,2,3,4,5 hours and 4 weeks Skin Gloss Meter (SGM) ,Microbiome on skin After applying the product for 0 and 4 weeks Skin swabing,Skin color After applying the product for 0 and 4 weeks Skin color meter ,Skin wrinkle After applying the product for 0,1,2,3,4,5 hours and 4 weeks Photography

Secondary Outcome Measures

Name	Time	Method
Satisfaction in volunteers After applying the product for 0 and 4 weeks Satisfaction in product