Food Anthocyanins and Flavanols as a Strategy for a Healthy Ageing: Cardiovascular Health and Cognitive Performance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Change from baseline of flow-mediated vasodilatation (FMD) of the brachial artery
研究概览
简要总结
The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.
详细描述
The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.
Healthy volunteers are recruited to participate in a parallel study (n 30 per group) for 10 to 12 weeks. Markers of cardiovascular health (FMD, markers of inflammation and fatty acid metabolism) and cognition (neuropsychological tests and plasma neurotrophins) are being measured before and after intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 50-85
- •BMI 20-32 Kg/m2
排除标准
- •Mini-mental state examination (MMSE) < 28
- •Systolic blood pressure (SBP) >139 mmHg
- •Diastolic blood pressure (DBP) > 89 mmHg
- •Total cholesterol > 6.5 mmol/L
结局指标
主要结局
Change from baseline of flow-mediated vasodilatation (FMD) of the brachial artery
时间窗: Over 6 minutes on day 0 and after10 weeks
The FMD of the brachial artery will be measured using an ultrasound collected at baseline and continuously for 60 seconds post-arm occlusion for 5 minutes. FMD will be expressed as percentage of variation between pre-and postischemic diameters
次要结局
- Change from baseline STROOP score after 10 weeks intervention(at inclusion and 10 weeks after intervention)
- Change from baseline Tower of London score after 10 weeks intervention(at inclusion and 10 weeks after intervention)
研究者
Spanish National Research Council
PhD
National Research Council, Spain