calcitonin in mastectomy pai
Phase 4
- Conditions
- acute post mastectomy pain and post operative inflammatory reaction.Other acute postprocedural painG89.18
- Registration Number
- IRCT20220212054002N1
- Lead Sponsor
- Mansoura university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 130
Inclusion Criteria
Female patients
Aged 18–65 years,
American Society of Anesthesiologists physical status I and II,
Undergoing unilateral breast cancer surgery (modified radical mastectomy, breast conservational surgery, simple mastectomy and axillary clearance)
Exclusion Criteria
patient refusal,
history of bronchial asthma
spinal deformities,
coagulation disorders,
allergy to local anesthetics,
history of opioid usage for chronic pain
cognitive/psychiatric disorders
infection at the injection site
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to rescue analgesia (opioid) in post operative period. Timepoint: time point measured from the end of surgery to request of analgesic. Method of measurement: visual analogue scale to measure pain assessment of pain if VAS is more than 3 patient will receive morphine 10 Mg intramuscular and reassess after 30 min for pain relieve .
- Secondary Outcome Measures
Name Time Method Total opioid requirement. Timepoint: 24 hour post operative. Method of measurement: amount of drug prescribed amount of morphine consumption in Mg in 24 hour after the end of surgery.;Inflammatory mediators (interleukin 6,interlokin 10, and tumor necrotic factor. Timepoint: before intervention and 2hour post operative ,12 hour post operative , and 24 hour post operative. Method of measurement: lab kit to measure inflammatory mediators.