A pilot study of the Effect of Perioperative Inhaled Tiotropium for patients with chronic Obstructive Pulmonary disease in Esophageal cancer surgery
Phase 2
Recruiting
- Conditions
- Esophageal cancer
- Registration Number
- JPRN-UMIN000037922
- Lead Sponsor
- The Cancer Institute Hospital of Japanese Foundation for Cancer Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
Not provided
Exclusion Criteria
1) Comorbidities a) Previous history of thoracic surgery. b) Patients with glaucoma. c) Patients with prostatic hypertrophy. d) Patients with heart failure and/or atrial fibrillation. e) Previously treatment for chronic obstructive pulmonary disease (COPD) or bronchial asthma. f) Patients with active infection. 2) Total pharyngolaryngoesophagectomy, two staged esophagectomy, and reconstruction without gastric conduit. 3) Others a) Patients with psychiatric disease. b) Patients who were judged inappropriate to entry this study by physician in charge. c) Previous history of hypersensitivity to atropine or drugs similar to atropine.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of pneumonia within 30 days after esophagectomy
- Secondary Outcome Measures
Name Time Method 1) Incidence of cardiovascular complications within 30 days after esophagectomy 2) Incidence of any postoperative complications within 30 days after esophagectomy 3) FEV1% (pretreatment, preoperative, postoperative) 4) Walking distances in incremental shuttle walking test (pretreatment, preoperative, postoperative) 5) Incidence of adverse events 6) Mortality within 30 days after esophagectomy