Metabolic and neurovascular brain plasticity in amyloid-positive older people with metabolic risk factors - EnergI

Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.0 个研究点目标入组 300 人开始时间: 2017年12月15日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Body Mass Index = 25 to max. 40 kg / m2
•- Presence of at least one metabolic risk factor (according to ATP III criteria (National Cholesterol Education Program (NCEP): Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III Final Report), 2002 )
•Abdominal obesity, determined by a waist circumference of over 102 cm in men or over 88 cm in women
•Fasting triglycerides greater than 150 mg/dl (> 1.7 mmol/l), or already initiated therapy to reduce triglycerides
•HDL cholesterol = 40 mg/dl (<1.05 mmol/l) in men or <50 mg/dl (1.25 mmol/l) in women
•Blood pressure of 130/85 mmHg or higher, or already initiated therapy to reduce hypertension
•Fasting glucose = 110 mg/dl (5.6 mmol/l)
•- Written declaration of consent for PET measurements with [18F]-FDG and [18F]-Florbetaben
•- Preserved legal capacity of the subjects at the time of each examination

•- Coronary heart disease in all manifestations
•- Cardiomyopathies
•- Supraventricular and ventricular arrhythmias
•- Clinically relevant cardiac defects
•- Blood pressure above 140/90 mmHg
•- heart insufficiency > stage IIb according to NYHA
•- Severe chronic obstructive pulmonary disease (COPD), bronchial asthma
•- Resting bradycardia (below 45 bpm)
•- Relevant orthopedic diseases
•- Serious internal diseases
•- MRI disqualification(claustrophobia, pacemakers, metallic endoprostheses)
•- Severe vision or hearing impairments (uncorrected)
•- Body mass index >40 or <25 kg/m2
•- Current major depressive disorder and / or severe neuropsychological disorder
•- Current severe neurological disease of the central nervous system
•- Current dependence (e.g. alcohol, psychoactive pharmaceuticals, cocaine, heroin)
•- Acute viral or bacterial infection
•- Intake of antidiabetics
•- Diabetes mellitus
•- Regular intake of benzodiazepines
•- Incapable of doing sports
•- Foot deformities of any kind
•- Persons for whom radioactive substances or ionizing radiation have been used for research or treatment purposes in the past ten years (§88 (2) Radiation Protection Ordinance), excluding purely diagnostic examinations
•- Serious liver disease (e.g. chronic hepatitis, cirrhosis of the liver) or renal dysfunction requiring dialysis
•- History of stroke or epilepsy

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