DRKS00013501
Not yet recruiting
未知
Metabolic and neurovascular brain plasticity in amyloid-positive older people with metabolic risk factors - EnergI
Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.0 sites300 target enrollmentDecember 15, 2017
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Metabolic risk factors defined by ATP-III-criteriaAmyloid deposition as indication of preclinical Alzheimer’s disease
- Sponsor
- Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.
- Enrollment
- 300
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Body Mass Index \= 25 to max. 40 kg / m2
- •\- Presence of at least one metabolic risk factor (according to ATP III criteria (National Cholesterol Education Program (NCEP): Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III Final Report), 2002 )
- •Abdominal obesity, determined by a waist circumference of over 102 cm in men or over 88 cm in women
- •Fasting triglycerides greater than 150 mg/dl (\> 1\.7 mmol/l), or already initiated therapy to reduce triglycerides
- •HDL cholesterol \= 40 mg/dl (\<1\.05 mmol/l) in men or \<50 mg/dl (1\.25 mmol/l) in women
- •Blood pressure of 130/85 mmHg or higher, or already initiated therapy to reduce hypertension
- •Fasting glucose \= 110 mg/dl (5\.6 mmol/l)
- •\- Written declaration of consent for PET measurements with \[18F]\-FDG and \[18F]\-Florbetaben
- •\- Preserved legal capacity of the subjects at the time of each examination
Exclusion Criteria
- •\- Coronary heart disease in all manifestations
- •\- Cardiomyopathies
- •\- Supraventricular and ventricular arrhythmias
- •\- Clinically relevant cardiac defects
- •\- Blood pressure above 140/90 mmHg
- •\- heart insufficiency \> stage IIb according to NYHA
- •\- Severe chronic obstructive pulmonary disease (COPD), bronchial asthma
- •\- Resting bradycardia (below 45 bpm)
- •\- Relevant orthopedic diseases
- •\- Serious internal diseases
Outcomes
Primary Outcomes
Not specified
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