utrition and asthma: subgroups and outcomes
- Conditions
- (Severe) asthma
- Registration Number
- NL-OMON27753
- Lead Sponsor
- Medical Centre Leeuwarden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
Asthma diagnosis according to GINA guidelines
- Step 3-5 treatment (GINA guidelines)
- Aged =18 year
- Proficient in speaking and understanding Dutch
Exclusion Criteria
- Pregnancy
- Concurrent respiratory disease (e.g. pneumonia, bronchitis, COPD)
- Pulmonary infection or asthma exacerbation in the past 4 weeks
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method utritional intake and status: <br>- Intake: dietary intake of macro- and micronutrients and food groups, and the Dietary Inflammatory Index;<br>- Status: body composition (fat mass and fat-free mass), anthropometry (BMI, waist- and hip circumference), muscle mass (urinary creatinine excretion), muscle strength (handgrip strength), functional exercise capacity (6-minute walking test), and nutrient status (plasma vitamins, minerals, lipids).
- Secondary Outcome Measures
Name Time Method Clinical, functional and inflammatory characteristics of asthma:<br>- Clinical: asthma control (ACQ), quality of life (AQLQ), hospital admissions, exacerbation frequency, and use of oral corticosteroids (health care utilization) <br>- Functional: pulmonary function (spirometry), and medication use;<br>- Inflammatory: airway inflammation (FeNO, sputum mRNA, leukocytes and cell differential), systemic inflammation (plasma albumin, IL-6, TNF-a, CRP), innate immune activity (plasma leukocytes and cell differential), and atopic status (IgE and RAST)