p53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Refractory/Relapsed Lymphoid Malignancies
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Objective Response by Revised Response Criteria for Malignant Lymphoma
研究概览
简要总结
The purpose of this study is to evaluate how well the study drug works and safety of oral decitabine in patients with refractory or relapsed lymphoid malignancies. The decitabine is being given at a lower dose than used for its approved use. It is also being given with another drug, tetrahydrouridine (THU), to improve the exposure of lymphoma cells to decitabine.
详细描述
Primary objective: To determine the objective response rate to oral THU-Dec in patients with 3 separate biologic subsets of refractory/relapsed lymphoid malignancies:
- T-cell lymphoma,
- Aggressive B cell lymphoma,
- indolent B-cell lymphoma .
Secondary objectives:
(i) To evaluate the toxicity of oral THU-Dec in these patients; (ii) To evaluate hypotheses regarding mechanisms of resistance and predictive biomarkers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically or cytologically-proven T- or B-cell lymphoma
- •Subjects must have received 1 or more prior therapies for this disease and have had stable disease or progressive disease based upon the criteria from the Revised Response Criteria for Malignant Lymphoma78, or intolerable toxicities precluding further therapy with a prior regimen
- •Subjects must have measurable disease per Revised Response Criteria for Malignant Lymphoma78
- •ECOG performance status 0 - 2
- •Adequate organ function as defined by the following criteria:
- •Serum aspartate transaminase (AST; serum glutamic oxaloacetic transaminase [SGOT]) and serum alanine transaminase (ALT; serum glutamic pyruvic transaminase [SGPT]) ≤ 2.5 x laboratory upper limit of normal (ULN)
- •Total serum bilirubin ≤ 2.0 x ULN (except if Gilbert's disease)
- •Absolute neutrophil count (ANC) ≥ 1500/uL
- •Platelets ≥ 50,000/uL
- •Hemoglobin ≥ 8.0 g/dL (transfusion permitted)
- •Serum calcium ≤ 12.0 mg/dL
- •Serum Creatinine ≤ 3.0 mg/dL
- •Patients with history of CNS lymphoma can be enrolled if the CNS disease has been controlled with therapy for a minimum of 4 weeks. Brain MRI is not required for eligibility.
- •Subjects must have the ability to understand and the willingness to sign a written informed consent document.
排除标准
- •Life expectancy ≤ 4 months in the judgment of the treating clinician
- •Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness (HIV-positive subjects on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with oral THU-Dec. Appropriate studies will be undertaken in subjects receiving combination antiretroviral therapy when indicated.
- •Pregnancy or breastfeeding (pregnant or breastfeeding women are excluded from this study because oral THU-Dec has the potential for teratogenic or abortifacient effects. Because there is an unknown, but potential, risk for adverse events in nursing infants secondary to treatment of the mother with oral THU-Dec, breastfeeding should be discontinued if the mother is treated with oral THU-Dec.
- •Other severe acute or chronic medical or psychiatric conditions or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the patient inappropriate for entry into this study.
- •Receiving other investigational agent
研究组 & 干预措施
Decitabine + Tetrahydrouridine
oral THU dosed by weight, followed by oral decitabine dosed by weight for 60 minutes (± 10 minutes) after the THU, twice weekly on consecutive days.
Treatment on protocol monitoring continues for 52 weeks.
干预措施: Decitabine (Drug)
Decitabine + Tetrahydrouridine
oral THU dosed by weight, followed by oral decitabine dosed by weight for 60 minutes (± 10 minutes) after the THU, twice weekly on consecutive days.
Treatment on protocol monitoring continues for 52 weeks.
干预措施: Tetrahydrouridine (Drug)
结局指标
主要结局
Objective Response by Revised Response Criteria for Malignant Lymphoma
时间窗: Up to 52 weeks
次要结局
- Complete Response(Up to 52 weeks)
- Duration of response(Up to 52 weeks)
- Disease-specific survival(Up to 52 weeks)
- Time to progression(Up to 52 weeks)
- Progression-free survival(Up to 52 weeks)
- Partial Response(Up to 52 weeks)
- Stable Disease(Up to 52 weeks)
- Progressive Disease(Up to 52 weeks)
- Disease-free survival(Up to 52 weeks)
- Time to treatment failure(Up to 52 weeks)
研究者
Yogen Saunthararajah
Professor of Hematology and Oncology
Case Comprehensive Cancer Center