Effective analgesia in patients after knee surgery
Completed
- Conditions
- Total knee replacement and painSurgery
- Registration Number
- ISRCTN17389296
- Lead Sponsor
- Clinic for Orthopaedics and Traumatology Lovran
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1. Patients who underwent elective surgery for primary degenerative osteoarthritis scheduled at Clinic of Orthopedics and Traumatology Lovran, Lovran, Croatia for total knee replacement (TKR), American Society of Anesthesiologists (ASA) physical status I to III
2. Fully able to understand the study contents were included in the study
3. Adults over 50
Exclusion Criteria
1. Patients with allergies to anesthetics and analgesics
2. Received blood transfusion
3. Those with neurologic conditions of the lower limbs
4. Immune disorders
5. Malignant disease
6. Secondary form of knee osteoarthritis or rheumatoid arthritis
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Pain intensity is measured using the VAS at rest and on movement before surgery,after surgery, 24 hours and 72 hours after surgery<br>2. Absolute number of leukocytes is measured using electronic counter Technicom H-1 system, USA, using laser's optical principle of dark colors<br>3. Frequency of different types of lymphocytes is measured using the flow cytometry before surgery,after surgery, 24 hours and 72 hours after surgery<br>4. Concentration of cytokines and hormones are measured using ELISA before surgery, after surgery, 24 hours and 72 hours after surgery
- Secondary Outcome Measures
Name Time Method 1. Patient outcome is measured using hospital electronic documentation system at before surgery, after surgery, 24 hours and 72 hours after surgery<br>2. Complications is measured using hospital electronic documentation system at before surgery, after surgery, 24 hours and 72 hours after surgery