Effect of Chlorhexidine 0.2% in a mucoadhesive polymeric gel from Carbomer and HPC on prevention of ventilator associated pneumonia

Phase 3

• Conditions: ventilator associated pneumonia.; Pneumonia in bacterial diseases classified elsewhere; J17.0

• Registration Number: IRCT20101211005363N14
• Lead Sponsor: Zanjan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 December 2019

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

Age between 20 to 50 years
Admission less than 24 hours in intensive care unit
Intubated patient
Satisfaction of patients' families

Exclusion Criteria

contraindications to any cause to enteral feeding
pneumonia

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Concentration of polymer in volume. Timepoint: At the beginning of experiment. Method of measurement: By weighing.;The amount of loading of cholorhexidine in gel. Timepoint: At the beginning of experiment. Method of measurement: By weighing.;The amount of release of cholorhexidine in gel. Timepoint: 1,2,3 and 4 hours after gel preparation. Method of measurement: Spectrophotometry.;Ventilator Associated Pneumonia. Timepoint: Third day, Sixth day, Ninth day, The twelfth day. Method of measurement: Clinical Pulmonary Infection Score.

Secondary Outcome Measures

Name	Time	Method
Mortality rate during hospitalization in Intensive Care Unit. Timepoint: End of the study. Method of measurement: Records.;Connection to ventilator days. Timepoint: End of the study. Method of measurement: Records.;Length of Intensive Care Unit stay. Timepoint: End of the study. Method of measurement: Records.