A multi-center randomized controlled clinical trial to examine the clinical, biochemical and antimicrobial effects of a mouth rinse on patients with mild periodontal disease.
Not Applicable
- Conditions
- mild periodontal disease
- Registration Number
- JPRN-UMIN000006407
- Lead Sponsor
- Osaka University Graduate School of Dentistry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Not provided
Exclusion Criteria
(1) Persons who took antibiotics and anti-inflammatory agent (except external use) for the past one month prior to this study. (2) Persons who use a dental floss or an interdental brush daily. (3) Persons who have the medical history of hypersensitivity to the ingredients (cetylpyridinium chloride, triclosan, dipotassium glycyrrhizinate and others.) containing the mouth rinse. (4) Persons who are suspected to be diabetic or pregnant. (5) Persons who have five or more untreated caries lesions (scored C2 and up). (6) Severe periodontitis patients with tooth mobility or abscess formation. (7) Persons who are judged to be unqualified for this study subjects by investigators.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Quigley-Hein plaque index (QHI) 2. Modified gingival index (MGI) 3. Probing pocket depth (PD) 4. Bleeding on probing (BOP) 5. Cytokine levels in gingival crevicular fluid 6. The number of total bacteria and some periodontopathic bacteria in subgingival plaque
- Secondary Outcome Measures
Name Time Method