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Clinical Trials/NCT02818465
NCT02818465
Completed
Not Applicable

Role of the Interaction Between AGEs and Their Receptor RAGE in the Development and the Progression of the Uremic Vasculopathy of Hemodialyzed Patients

CHU de Reims1 site in 1 country100 target enrollmentMarch 30, 2015
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ConditionsHemodialyzed Patients

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Hemodialyzed Patients
Sponsor
CHU de Reims
Enrollment
100
Locations
1
Primary Endpoint
Frammingham Score
Status
Completed
Last Updated
3 months ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Chronic kidney disease (CKD) is associated with an extensive vasculopathy and high cardiovascular mortality as well as an accumulation of uremic toxins. Among the latest, advanced glycation end-products (AGEs) interact with RAGE. Investigators aimed to analyze the role of RAGE in the calcification process of hemodialyzed patients, in a correlative and prospective study. Vascular calcifications will be assessed by Xray and tomodentimetry while accumulation of AGEs will be measured in the serum and in the skin (non invasive). Additionally factors influencing RAGE activation such as genetic polymorphism and level of soluble forms of RAGE will be measured and analyzed.

Registry
clinicaltrials.gov
Start Date
March 30, 2015
End Date
November 16, 2017
Last Updated
3 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Renal impairment
  • •Hemodialysis for more than 3 months
  • •Have agreed to participate in research
  • •Affiliated to a social security scheme

Exclusion Criteria

  • •Diabetes , for diabetes induces accelerated formation of advanced glycation end products , which could then be a confounding factor in our study.
  • •Protected by law .
  • •pregnant women
  • •Matt or pigmented skin because the skin hyperpigmentation interfere with reading the skin fluorescence giving falsely elevated values .
  • •Having an aneurysm of the abdominal aorta known
  • •Suffering from a progressive neoplastic disease

Outcomes

Primary Outcomes

Frammingham Score

Time Frame: up to 12 months

Study Sites (1)

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