NCT00193362已完成3 期
Phase III Randomized Study of Paclitaxel, Carboplatin, and Gemcitabine Versus Gemcitabine and Vinorelbine as First-Line Chemotherapy for Stage IIIB and IV Non-Small Cell Lung Cancer
适应症
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 200
- 主要终点
- Overall survival.
研究概览
简要总结
The purpose of this study is to compare the effectiveness of the three-drug combination paclitaxel, carboplatin, and gemcitabine to the two-drug combination gemcitabine and vinorelbine in patients with advanced Non-Small Cell Lung Cancer
详细描述
Upon determination of eligibility, patients will be randomly assigned to one of two treatment arms:
- Paclitaxel + Carboplatin + Gemcitabine
- Gemcitabine + Vinorelbine
For ever 2 patients treated, 1 will receive treatment A (Paclitaxel + Carboplatin + Gemcitabine) and 1 will receive treatment B (Gemcitabine + Vinorelbine). The study is not blinded so both the patient and the doctor will know which treatment has been assigned.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •To be included in this study, you must meet the following criteria:
- •Non-small cell bronchogenic carcinoma
- •Newly diagnosed unresectable stage IIIB or stage IV disease
- •Patients with stage IIIB disease should be ineligible for combined therapy
- •Patients must have measurable lesion definable by X-ray or CT scan.
- •No prior antineoplastic chemotherapy for lung cancer prior to study entry
- •Age > 18 years
- •Able to perform activities of daily living with minimal assistance
- •Adequate bone marrow, liver and kidney function
- •Written informed consent must be obtained prior to study entry
- •Patients must be available for treatment and followup.
排除标准
- •You cannot participate in this study if any of the following apply to you:
- •Female patient pregnant or lactating
- •History of heart disease
- •Serious active infection at the time of treatment
- •Other serious underlying medical condition
- •Brain metastasis
- •Patients without measurable disease
- •Uncontrolled diabetes mellitus defined as random blood sugar > 250mg/dL
- •Dementia or significantly altered mental status
- •Significant peripheral neuropathy by history or physical examination.
- •Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
结局指标
主要结局
Overall survival.
次要结局
- Overall toxicity
- Overall response rate
- Time-to-progression
- Assess the quality of life
研究者
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