Revascularization Strategies for ST Elevation Myocardial Infarction; The Cardiac Magnetic Resonance Endpoint Study

Unity Health Toronto3 sites in 1 country250 target enrollmentApril 2014

ConditionsAcute Myocardial Infarction

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Acute Myocardial Infarction
Sponsor: Unity Health Toronto
Enrollment: 250
Locations: 3
Primary Endpoint: Infarct size by CMR
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Revascularization strategies for ST elevation myocardial infarction (STEMI) study (ASSIST-CMR) will compare the effects of two revascularization strategies [same sitting multivessel primary PCI (SS-PCI) and culprit vessel only primary PCI (IRA-PCI)] on myocardial infarct size (MIS) as determined by cardiac magnetic resonance (CMR) imaging in patients presenting with STEMI and multivessel disease (MVD).

Registry

clinicaltrials.gov

Start Date

April 2014

End Date

July 2018

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Unity Health Toronto

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•High risk ST elevation myocardial infarction evidenced by: ≥2 mm ST elevation in 2 anterior or lateral leads; or ≥2 mm ST elevation in 2 inferior coupled with ST depression in 2 contiguous anterior leads for a total ST deviation of ≥8 mm; or New left bundle branch block with at least 1 mm concordant ST elevation.
•Multivessel CAD as evidenced by ≥1 significant (≥70% by visual assessment or FFR\<0.80 for 50-70% stenosis) stenosis in non-IRA.
•Successful IRA-PCI with \<10% residual angiographic stenosis and TIMI III flow.
•Written informed consent.

Exclusion Criteria

•Age ≤ 18 years.
•Prior coronary artery bypass graft (CABG) surgery.
•Administration of thrombolytic therapy.
•Non-IRA stenosis is a chronic total occlusion or located in left main artery.
•Hemodynamic instability evidenced by BP\<90 mmHg, Killip class ≥2, need for inotropes/vasopressors.
•Known renal insufficiency (estimated GFR \< 50ml/min).
•Contraindication to CMR.