An open randomised controlled clinical trial to evaluate efficacy of shunthyadi kwath in mutrashmari w.s.r to urolithiasis
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- 1.To compare the efficacy of Shunthyadikwath with Varunadikwath in the management of Mutrashmari.
研究概览
简要总结
Ayurveda being the ancient science of healing has described the diseases of urinary track under three main headings that is Mutrakriccha, Mutraghata and Mutrashmari. Of them Mutrashmari being one of the commonest anomalies in present era.
Acharya Sushruta the father of surgery has described comprehnsively about Mutrashmari, its etiology, symptomology, pathology, classification, complications and management
Acharya Sushruta has included Ashmari in Ashtomahagadi one of the eight troublesome disease and Ashmari is kaphapradhan tridoshaj vyadhi .
In modern science the disease can be correlated with Urolithiasis.
Urolithiasis is one of the commonest problems around the globe and the incidence of calculi differs as per age, sex and geographical distribution, Urolithiasis reached to its peak in population aged above 30 yrs, the male to female ration is 0.9 and overall recurrence rate in male to female is 2 as to one
Before proceeding to surgical procedure like Lithotripsy firstly we should try to manage with oral medication.
Need of study
In modern era there are many techniques like open surgery, cytolithotomy, ureterolithotomy available for treating urolithiasis.
Most of these techniques are expensive and costly limiting to higher economy class people.
All these procedures can remove formed stone but do not break the samprapti which brings the formation of stones.
Hence therefore it is very necessary to findout an alternate, inexpensive, safe and effective therapy affordable to people of all economic class.
In Bhaisajya ratnavali mentioned about the usage of Shunthyadi kwath helpful for removing Mutrashmari as it contains all the ingredients having Katu, Tikta and MadhurRasa, Katuvipaka and Ushnaveerya and it is Bhedana in Karma, the Shunthyadi kwath ingredients is easily available
The procedure of preparation of Shunthyadi kwath is very simple as there is need to evaluate an alternative and safe effective therapy for mutrashmari, reachable for people of all economic class
Number of patients
Group A Study group 25 patients will be administered shunthyadi kwath
Group B Control group 25 patients will receive Varunadi kwath
Investigations
USG Abdomen and pelvis
X-RAY
KUB
URINE Routine and microscopic
CBC
BSL
KFT
CONCLUSION AND SUMMARY
On the basis of available literature, observation and discussion will be precisely drawn and whole dissertation will be summarized.
FINAL OUTCOME
1 Decrease in size of stone
2 Improvement in symptom like pain and micturition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient of either sex.
- •Age between
- •Patient of Mutrashmariwith USG evidence of single calculus/multiple calculi of 4 mm to max 10 mm.
- •Patient of Mutrashmari with renal, uretric, and UVJ calculus.
排除标准
- •Patients of obstructive pathology with changes of severe hydronephrosis in USG.
- •Patient is having uncontrolled diabetes, Asthma and other major systemic illness.
- •Impaired renal function.
- •Pregnant and lactating mother.
- •Urinary calculi having size more than 10 mm.
- •Kshar ayogya vyadhi like Jwara, Raktapitta, Urahkshat, Murchha, UTI.
结局指标
主要结局
1.To compare the efficacy of Shunthyadikwath with Varunadikwath in the management of Mutrashmari.
时间窗: 45 days
次要结局
- 1. To find out whether this drug reduces the size of Mutrashmari or promotes its expulsion.(2. To find out its effect on the symptoms of Mutrashmarilike burning micturition,pain hematuria etc.)
研究者
Rohit Dilip Gaikwad
R.A.Podar govt.ayurvedic college Worli mumbai