A Nutrition Intervention for Arthritis-4
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Pain Score
研究概览
简要总结
The purpose of the study is to assess whether, in individuals with rheumatoid arthritis, a low-fat, vegan diet improves pain and other subjective symptoms more effectively than a control supplement or a placebo. The principal measure is pain as measured by Visual Analog Scale (VAS) and disease activity as measured by number of painful swollen and tender joints, respectively. The study duration is 36 weeks.
This study tests that a low fat, plant-based (vegan) diet free of foods commonly identified as triggers improves mood, using the Center for Epidemiologic Studies Depression Scale-Revised (CESD-R), and the Beck Depression Inventory II (BDI-II).
详细描述
Preliminary evidence suggests that low-fat, vegetarian diets and certain nutritional supplements can help reduce pain and also reduce the need for pain medications for some people. The investigators will ask about 100 people to participate. All of them will get a low-fat, vegan diet and a nutritional supplement (mixture of omega-3 oils and vitamin E or a placebo), although some will get the diet first, and others will get the supplement first. This order in which they will get the diet and the supplement will be determined randomly, that is, by chance (like the toss of a coin). The principal measure is pain as measured by Visual Analog Scale (VAS) and disease activity as measured by number of painful swollen and tender joints, respectively. The Beck Depression Inventory II (BDI-II)will be used to measure changes in mood. The study duration is 36 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A diagnosis of rheumatoid arthritis based on 2010 ACR / EULAR Rheumatoid Arthritis Classification Criteria. Classification as "definite RA" is based on:
- •the confirmed presence of synovitis in at least 1 joint
- •absence of an alternative diagnosis that better explains the synovitis
- •and achievement of a total score of 6 or greater (of a possible 10): 24 Joint involvement, designating the metacarpophalangeal joints, proximal interphalangeal joints, the interphalangeal joint of the thumb, second through third metatarsophalangeal joint and wrist as small joints, and elbows, hip joints and knees as large joints:
- •Involvement of 1 large joint gives 0 points
- •Involvement of 2-10 large joints gives 1 point
- •Involvement of 1-3 small joints (with or without involvement of large joints) gives 2 points
- •Involvement of 4-10 small joints (with or without involvement of large joints) gives 3 points
- •Involvement of more than 10 joints (with involvement of at least 1 small joint) gives 5 points
- •Serological parameters - including the rheumatoid factor as well as anti-citrullinated protein antibody (ACPA):
- •Negative RF and negative ACPA gives 0 points
- •Low-positive RF or low-positive ACPA gives 2 points
- •High-positive RF or high-positive ACPA gives 3 points Acute phase reactants: 1 point for elevated erythrocyte sedimentation rate (ESR) or elevated C-reactive protein (CRP) value Duration of arthritis: 1 point for symptoms lasting six weeks or longer
- •Continuing or recurring pain (i.e., joint pain daily, unless on pain medication).
- •Age at least 18 years
- •Ability and willingness to participate in all components of the study
- •Willingness to be assigned to either the diet group or supplement group
- •Pain medications unchanged within last 6 weeks.
排除标准
- •< 18 years of age
- •Alcohol consumption of more than 2 drinks per day or the equivalent, episodic increased drinking (e.g., more than 2 drinks per day on weekends), or a history of alcohol abuse or dependency followed by any current use
- •Use of recreational drugs in the past 6 months (past drug use, if fully recovered, is not a criteria for exclusion)
- •Pregnancy
- •Unstable medical or psychiatric illness
- •Likely to be disruptive in group sessions (as determined by research staff)
- •Already following a low-fat, vegan diet
- •Lack of English fluency
- •Inability to maintain current medication regimen
- •Inability or unwillingness to participate in all components of the study
结局指标
主要结局
Pain Score
时间窗: Change in pain score from Baseline at 4 months
will be measured by visual analog scale from 0%, indicating no pain, to 100%, indicating pain as bad as it could possibly be
Improvement in mood
时间窗: Change in mood from Baseline at 4 months
measured by the Beck Depression Inventory II (BDI-II), with scores ranging from 0 indicating minimal depression to 63, indicating severe depression.
Disease Activity score
时间窗: Change in disease activity score from Baseline at 4 months
measured by number of painful, swollen and tender joints from scores below 2.6, indicating disease remission, to more than 5.1, indicating severe disease activity.
次要结局
- Quality of Life of Mood(Change in quality of life from Baseline at 4 months)