Comparative evaluation of Demineralised Freeze Dried Bone Allograft with & without Doxycycline hyclate loaded Proniosomal gel in the treatment of Class II Furcation defects: A Randomized Controlled Trial.

This randomized clinical study will include 28 patients both males and females visiting the department of Periodontics and Implant Dentistry diagnosed with Stage III Periodontitis and exhibiting Class II furcation defects. Two sites in each patient will be assigned randomly for sampling as follows- It will be conducted in Department of Periodontics and Implant Dentistry, after taking informed consent from the patient. All the clinical and radiographical parameters will be evaluated at baseline after which the sites in the patients will be randomly and equally divided into Test and Control groups to be treated with doxcycline hyclate gel with DFDBA and DFDBA alone respectively in Class II furcation defects in Stage III Periodontiits patients. The study will be initiated after clearance from the Institutional Ethics Committee. For each patient two sites will be randomly assigned as;

Group I: (28 - Control Group) – Stage III Periodontitis exhibiting Class II furcation defects to be treated with DFDBA bone graft alone. Group II: (28- Test Group) – Stage III Perioodntitis exhibiting Class II furcation defects to be treated with doxcycline gel with DFDBA . INCLUSION CRITERIA: 1) Patients with Stage III periodontitis as assessed by Probing Pocket Depth (PPD) ? 6mm, interdental clinical attachment level (CAL) ? 5 mm and Horizontal Probing Depth (HPD) ? 2mm. 2) Patients with at least two class II furcation defects in either maxillary or mandibular arch. EXCLUSION CRITERIA: 1) Patients with a history of allergies, Systemic diseases or drug usage. 2) Patients who have undergone periodontal surgery in previous 6 months. 3) Pregnant or lactating women. 4) Smokers, tobacco chewers and patients with poor oral hygiene index (PI>1.5) will be excluded from the study. 5) Carious teeth or teeth with mobility > Class II