Thrombolysis in stRoke With Unknown onSet Based on noncontrasT CT
- Conditions
- Stroke, Acute
- Registration Number
- NCT03634748
- Lead Sponsor
- University Hospital Tuebingen
- Brief Summary
Multicentric, observational, registry-based study of 0.9 mg/kg i.v. thrombolysis in wake-up stroke or stroke with unknown onset based on non-contrast CT appearance only
- Detailed Description
Thrombolysis in wake-up stroke (WUS) or stroke with unknown onset (SUO) has been recently proven to be safe and effective using magnetic resonance imaging (MRI). However, in most of the thrombolyzing hospitals worldwide MR imaging is not available. We hypothesize that pragmatic non-contrast CT (NCCT)-based WUS/SUO thrombolysis may be feasible and safe.
Methods: TRUST-CT is an international multicenter registry-based study. WUS/SUO patients undergoing NCCT-based thrombolysis with NIHSS ≥ 4 and initial ASPECTS ≥ 7 are included and compared to propensity score matched non-thrombolyzed WUS/SUO controls. Primary endpoint is symptomatic intracranial hemorrhage (ICH); secondary endpoints include 24-hour NIHSS change of ≥ 4 and modified Rankin Score (mRS) at 90 days.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 117
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sICH 72hours symptomatic ICH according to ECASS3
- Secondary Outcome Measures
Name Time Method mRS 90 days 90 days mRS 90 days
Trial Locations
- Locations (5)
University Hospital Bratislava
🇸🇰Bratislava, Slovakia
General Hospital Liptovsky Mikulas
🇸🇰Liptovský Mikuláš, Slovakia
St. Johns Hospital Vienna
🇦🇹Vienna, Austria
University Hospital Tuebingen
🇩🇪Tuebingen, Germany
Lausanne University Hospital
🇨🇭Lausanne, Switzerland