NCT03832699Unknown不适用
Oral Dydrogesterone vs. Vaginal Micronized Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer: a Non-inferiority Randomized Clinical Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Live birth rate
研究概览
简要总结
The current trial is intended to assess the efficacy of oral versus vaginal progesterone for luteal support in frozen IVF cycles.
详细描述
Progesteron is used for luteal phase support in IVF cycles. Progesterone can be administered vaginally and orally. Duphaston is an oral progesterone drug, which has recentlly been proven effective in fresh cycle IVF. Yet, less is known regarding its efficacy in frozen cycle IVF. Thus, the objective of our trial is to compare the efficacy of vaginal and oral progesterone in frozen IVF cycles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Ages 18-39
- •Modified natural cycle (induction of ovulation with HCG)
- •Consent to participation
排除标准
- 未提供
研究组 & 干预措施
Oral progesterone
Experimental
干预措施: Dydrogesterone 10 MG (Drug)
Vaginal progesterone
Active Comparator
干预措施: Endometrin 100Mg Vaginal Insert (Drug)
结局指标
主要结局
Live birth rate
时间窗: Up to 9 months
Birth of a live infant after 24 weeks gestation
次要结局
- Clinical pregnancy rate(Outcome assesed 6-7 weeks following treatment)
- Implantation rate(Outcome assessed 6-7 weeks following treatment)
研究者
Hadas Ganer Herman
Principal investigator
Wolfson Medical Center
研究点 (1)
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