The effect of thalidomide on paraquat-induced mortality and measurement of oxidative stress and blood factors
Phase 3
Recruiting
- Conditions
- Paraquat herbicide poisoning.
- Registration Number
- IRCT20220307054208N1
- Lead Sponsor
- Kerman University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Definitive use of paraquat herbicide with toxic dose (based on history, clinical examination, endoscopic findings)
Patients' satisfaction to participate in the study
Exclusion Criteria
Poisoning with other herbicides other than Paraquat (based on history, clinical examination, endoscopic findings)
Non-toxic dose of paraquat (endoscopy and normal tests)
Lack of cooperation of patients to take medicine due to oral ulcers
Patient dissatisfaction to participate in the study
Existence of underlying lung diseases
Pregnant women
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of malondialdehyde. Timepoint: After the intervention. Method of measurement: Spectrophotometry.;Measurement of glutathione content. Timepoint: After the intervention. Method of measurement: Spectrophotometry.;Intravenous blood gas levels. Timepoint: After the intervention. Method of measurement: Laboratory experiment.;Percentage of arterial oxygen saturation. Timepoint: After the intervention. Method of measurement: Laboratory experiment.;Mortality rate. Timepoint: After the intervention. Method of measurement: Mortality rate.
- Secondary Outcome Measures
Name Time Method