Brain Oxygenation changes during Heart Surgery

Not Applicable

Recruiting

• Conditions: Heart Surgery; Anaesthesiology - Anaesthetics; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12619000605190
• Lead Sponsor: Justin Skowno

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-04-23
• Last Update Posted: 14 November 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

adults and children undergoing heart surgery using cardiopulmonary bypass

Exclusion Criteria

cerebral and cranial malformations involving frontal bone and cortex.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The correlation between cytochrome pressure reactivity and the autoregulation index COx will be determined using the methodology established by Highton(Adv Exp Med Biol, 2013) and Mitra(J Cer Blood Flow Met 2017), which, measures the similarity between blood pressure and [oxCCO] using a signal processing technique [during cardiopulmonary bypass]

Secondary Outcome Measures

Name	Time	Method
incidence of relative CCO (Cytochrome C Oxidase) deoxygenation during CPB (Cardiopulmonary Bypass), by two measurements: per patient event incidence (discrete reductions below baseline events per patient) and an area under the curve analysis (AUC for CCO<baseline reading per patient)[during cardiopulmonary bypass]