The Effect of Repetitive Transcranial Magnetic Stimulation on Dual-task Performance in Patients With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Change in Cognitive Function Measured by the Montreal Cognitive Assessment (MoCA)
研究概览
简要总结
This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex on cognitive function and dual-task performance in individuals with Parkinson's disease. Participants completed ten rTMS sessions over two weeks or received sham stimulation. Cognitive status was assessed using the Montreal Cognitive Assessment, and mobility was evaluated through single-task and multiple dual-task Timed Up and Go tests. The study examined whether rTMS could enhance cognitive abilities and improve motor-cognitive performance, which are commonly impaired in Parkinson's disease and contribute to reduced functional independence. Findings indicated that rTMS led to improvements in cognition, single-task mobility, and complex dual-task performance. The intervention was well tolerated, and no adverse events related to the stimulation intensity were reported.
详细描述
Parkinson's disease often leads to declines in cognition, gait performance, and the ability to manage simultaneous cognitive-motor demands. These difficulties contribute to mobility limitations, fall risk, and loss of independence in older adults. This randomized controlled study investigates whether repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex can enhance cognitive function and improve single- and dual-task mobility performance in individuals with Parkinson's disease. Participants complete a two-week intervention consisting of active or sham stimulation. Standardized cognitive and functional mobility assessments are administered before and after the intervention to determine the extent of change associated with rTMS. The study is designed to provide preliminary evidence on whether neuromodulation of an executive-control region can support functional motor-cognitive interactions in this population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of Parkinson's disease.
- •Age 65 years or older.
- •Currently receiving dopaminergic therapy.
- •Ability to stand independently for at least 30 seconds.
排除标准
- •Inability to walk for 2 minutes without a walking aid.
- •Any contraindication to transcranial magnetic stimulation (e.g., metal implants in the head, history of seizures).
- •Musculoskeletal injury or structural abnormality that could affect mobility assessment.
- •Presence of another neurological disease.
结局指标
主要结局
Change in Cognitive Function Measured by the Montreal Cognitive Assessment (MoCA)
时间窗: Baseline and after 2 weeks of intervention
The Montreal Cognitive Assessment (MoCA) is a validated screening tool assessing attention, executive function, memory, language, visuospatial abilities, and orientation. Scores range from 0 to 30, with higher scores indicating better cognitive performance. The outcome is defined as the change in total MoCA score from baseline to post-intervention.
次要结局
未报告次要终点
研究者
Halil Ibrahim ERGEN
Assistant professor
University of Gaziantep