Effect of Bupropion Treatment on Brain Activation Induced by Cigarette-Related Cues in Smokers
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 34
- 主要终点
- Craving ratings
研究概览
简要总结
Randomized, double-blind, before-after controlled trial to assess changes in regional brain activation in response to cigarette-related cues from before to after treatment with bupropion (vs placebo).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Care Provider)
盲法说明
Matching placebo pills
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Treatment-seeking cigarette smoker
- •Meet DSM-IV criteria for nicotine dependence
- •Negative result on urine test for drug use during screening
排除标准
- •History of any Axis I psychiatric diagnosis other than nicotine dependence
- •Medical conditions that might affect brain function
- •Current use of medications that could alter brain function
- •Pregnancy
- •Current illicit drug use other than occasional use of marijuana
研究组 & 干预措施
Bupropion
Participants assigned to 150mg of bupropion daily for the first 3 days, followed by titration up to 2 pills daily, separated by 8 hours, for the remaining 8 weeks of treatment.
干预措施: Bupropion (Drug)
Placebo
Participants assigned to pill placebo daily for the first 3 days, followed by titration up to 2 pills daily, separated by 8 hours, for the remaining 8 weeks of treatment.
干预措施: Placebo (Other)
结局指标
主要结局
Craving ratings
时间窗: 8 weeks
Participants were instructed to respond from 1 (definitely not) to 5 (definitely) on the question, "I crave a cigarette right now", after viewing video cues.
次要结局
- Exhaled carbon monoxide (CO)(8 weeks)
- Cigarettes per day(8 weeks)
- Fagerström Test for Nicotine Dependence (FTND)(8 weeks)