Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients

• Conditions: Osteoarthritis
• Interventions: Other: arthrocentesis; Other: ultrasonography of the knee

• Registration Number: NCT01993342
• Lead Sponsor: Parc Taulí Hospital Universitari

Brief Summary

The purpose of this study is to determine the concentration of different adipocytokine (adiponectin, leptin, resistin, visfatin, osteopontin) and an inflammation classic markers as Interleukine 1 beta, tumor necrosis alfa, interleukine 6 and high sensibility reactive c protein in the synovial fluid of knee osteoarthritis patients, and compare with the inflammation detected with ultrasonography evaluation of the joint. In last years, some studies appeared focusing on the role of adipocytokines in osteoarthritis and they correlated adipocytokines with cartilage degradation and x-ray degree; in our study we will focused in the importance of adipocytokines in the inflammatory changes more than in joint destruction.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Status Verified: 2013-11
• Primary Completion: 2013-11
• Study First Submitted: 2013-11-08
• Study First Submitted QC: 2013-11-19
• Last Update Submitted: 2013-11-19
• Study First Posted: 2013-11-25
• Last Update Posted: 2013-11-25
• Study Completion: 2014-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• aged 50 to 81
• primary osteoarthritis of the knee
• synovial effusion in examination
• patient who have the results in our database

Exclusion Criteria

• any other rheumatic conditions as rheumatoid arthritis or another inflammatory disease
• secondary knee osteoarthritis
• history of knee surgery
• any conditions that at investigator criteria exclude the patient from study procedures

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Inflammatory knee osteoarthritis	arthrocentesis	We recruited patients with osteoarthritis and synovial effusion to diagnostic the effusion and to confirm that this this synovial fluid had mechanical characteristics. Now we are going to determine the adipocytokines and traditional parameters of inflammation in this synovial fluid to correlate it, and we will associate it with the ultrasound explanation of the knee that we have in our database.
Inflammatory knee osteoarthritis	ultrasonography of the knee	We recruited patients with osteoarthritis and synovial effusion to diagnostic the effusion and to confirm that this this synovial fluid had mechanical characteristics. Now we are going to determine the adipocytokines and traditional parameters of inflammation in this synovial fluid to correlate it, and we will associate it with the ultrasound explanation of the knee that we have in our database.

Primary Outcome Measures

Name	Time	Method
Determination of adipocytokine levels (adiponectin, leptin, resistin, visfatin, osteopontin) in synovial fluid	We determine adipocytoquines in one month, all patients in the same determination kit	We have all the synovial fluid freeze, so now we have to determine the levels of everyone.

Secondary Outcome Measures

Name	Time	Method
Knee inflammation parameters detected by ultrasonography	three months	We performed the ultrasonography evaluation at the same time than the visit were realized, and we have the results in a data base, so we will wait for the adipocytokine results and we will compare with ultrasound evaluation
To determine additional classic parameters of inflammation in synovial fluid as Interleukine 1 beta, Interleukine 6 and tumor necrosis factor alfa	We determine this inflammatory parameters in one month in all patient at the same time	We will use classic inflammation parameters to compare with adipocytokine levels

Trial Locations

Locations (1)

Hospital Parc Tauli Sabadell; 🇪🇸 Sabadell, Barcelona, Spain