Fatigue and Exercise Training in Patients With Sarcoidosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change in fatigue
研究概览
简要总结
The aims of the current study is to explore if different exercise training protocols affect fatigue post-exercise, and if sarcoidosis-related fatigue and maximal and sub-maximal cardiopulmonary exercise test (CPET) variables change after a 4-weeks exercise training period.
详细描述
This project aims to provide data on post-exercise fatigue after single exercise sessions with endurance training and muscle strength training, each with two different intensities. For endurance training; post-exercise fatigue will be assessed after one session of high intensity interval training, and one session with longer duration of moderate intensity. For muscle strength training, fatigue will be measured after one session with high loads/few repetitions and one session with low loads/many repetitions. In addition, changes in sub-maximal and maximal metabolic and ventilatory responses to a maximal cardiopulmonary exercise test on a treadmill (CPET) and association to sarcoidosis-related fatigue before and after a 4-weeks exercise training period will be studied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with sarcoidosis diagnosed according to the latest American Thoracic Society/European Respiratory Society/World Association for Sarcoidosis and Other Granulomatous Disorders (ATS/ERS/WASOG) statement on sarcoidosis who are attending a four weeks exercise based pulmonary rehabilitation program at LHL-klinikkene Glittre.
排除标准
- •Patients with a concurrent and predominant diagnosis of another significant respiratory disorder (for example: asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, or lung cancer).
- •Unstable cardiovascular disease.
- •Not able to perform the required physical tests and exercise training sessions caused by co-morbidities.
研究组 & 干预措施
Exercise training
Four exercise training sessions. Two endurance training sessions, one with high intensity interval training and one session of moderate intensity of longer duration. Two strength training session; one with high load and few repetitions and one with low load and many repetitions.
Fatigue and lactate will be measured before, after and 24 hours post-exercise. Trainings sessions will be randomized.
干预措施: Muscle strength training (Other)
Exercise training
Four exercise training sessions. Two endurance training sessions, one with high intensity interval training and one session of moderate intensity of longer duration. Two strength training session; one with high load and few repetitions and one with low load and many repetitions.
Fatigue and lactate will be measured before, after and 24 hours post-exercise. Trainings sessions will be randomized.
干预措施: Endurance exercise training (Other)
结局指标
主要结局
Change in fatigue
时间窗: Fatigue measured immediately before and acute after exercise sessions, (within 1 min.), and addition 24 hours post-exercise.
Changes of fatigue will be assessed assessed by Visual Analogue Scale (VAS), where the grade of fatigue is assessed between 0 (no fatigue) and 10 (maximal fatigue).
次要结局
- Change in blood lactate(Blood lactate are measured before and acute after exercise sessions (within 2 min.), and in addition 24 hours post-exercise.)
- Change in sarcoidosis related fatigue(Measured first day and last day of a 4-week exercise based pulmonary rehabilitation)
- Change in maximal oxygen uptake(Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation)
- Change in metabolic and ventilatory variables from CPET(Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation)
研究者
Anne Helene Edvardsen
Head of Out Patient and Laboratory Department, Researcher
LHL Helse