Cardiac Biochemical and Omics-based Biomarkers in Patients Presenting Symptoms of Acute Coronary Syndrome in the Emergency Department (ACS Registry)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Coronary Syndrome
- Sponsor
- University Hospital Heidelberg
- Enrollment
- 2500
- Locations
- 1
- Primary Endpoint
- all-cause mortality
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The single-center MIR-registry was created to assess real-world prevalence, demographic characteristics and management of patients with acute coronary syndrome presenting in the emergency department (ED) of University of Heidelberg.
Detailed Description
To conduct a comprehensive characterization of patients with symptoms of acute coronary syndrome or elevated troponin levels. Records include clinical routine parameters, there will be an expansion involving the collection of blood samples for the analysis of novel laboratory-based and omics-based biomarkers. The ACS registry is monothetically managed by the Department of Internal Medicine III at Heidelberg University Hospital and is intended to serve as a basis for further clinical diagnostic and outcome studies. The blood samples will serve as the foundation for a comprehensive analysis of established and novel laboratory-based markers, as well as omics-based biomarkers (miRNA, metabolomics, and proteomics). Follow-up was performed via review of medical reports, phone calls and postal queries. The outcome parameters comprised rates for all-cause mortality, non-hemorrhagic stroke, myocardial infarction, and hospitalization for any cause.
Investigators
Mustafa Yildirim
Dr. med. univ.
University Hospital Heidelberg
Eligibility Criteria
Inclusion Criteria
- •The study will include consecutive patients who present to the cardiology emergency department at Heidelberg University Hospital with symptoms of acute coronary syndrome or a troponin increase (hs-TnT \>14 ng/L). Additional inclusion criteria are a minimum age of 18 years and providing informed consent through written consent to participate in the study. The following medical conditions are intended to be distinguished from one another:
- •Acute myocardial infarction
- •Unstable angina pectoris
- •Myocarditis
- •Heart failure
- •Cardiomyopathies
- •Pulmonary embolism
- •Renal insufficiency
- •Supraventricular and ventricular tachycardias
- •Hypertensive crisis
Exclusion Criteria
- •Exclusion criteria are defined according to GCP (Good Clinical Practice), i.e., mental illnesses/dementia (lack of capacity to provide informed consent), pregnancy/breastfeeding, as well as acute conditions requiring immediate treatment (e.g., cardiogenic shock).
Outcomes
Primary Outcomes
all-cause mortality
Time Frame: 12 months
all-cause mortality during follow-up
Secondary Outcomes
- stroke(12 months)
- Rehospitalization(12 months)
- myocardial infarction(12 months)