Study of the effect of fluoroquinolones on the risk of aortic disease development using claims database
Phase 4
- Conditions
- Outpatients receiving oral antibiotic prescription
- Registration Number
- JPRN-UMIN000051618
- Lead Sponsor
- Shizuoka Graduate University of Public Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 155126
Inclusion Criteria
Not provided
Exclusion Criteria
-Patients who received a prescription for fluoroquinolones or amoxicillin (+/- clavulanic acid) in the 4 months prior to the start of observation (antibiotic prescription episode) -Patients who were hospitalized in the 12 months prior to the start of observation -Cases with history of aortic aneurysm or aortic dissection up to prescription of oral antibiotic (these cases will be analyzed as an additional analysis) -Cases with Marfan syndrome, vascular type Ehlers-Danlos syndrome, and Lois-Dietz syndrome up to prescription of oral antibiotic -Cases that do not allow for a baseline period of 12 months prior to the start of observation
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Aortic events (hospitalization due to aortic aneurysm or aortic dissection) from oral antibiotic prescription to 2 months later
- Secondary Outcome Measures
Name Time Method