Gene Expression in Patients With Epiretinal Membranes

• Conditions: Proliferative Diabetic Retinopathy

• Registration Number: NCT01946451
• Lead Sponsor: Medical University of Silesia

Brief Summary

The purpose of this study was to investigate the expression of selected genes both in epiretinal membranes (ERMs) and peripheral blood mononuclear cells (PBMCs) from patients with primary and secondary epiretinal membranes in proliferative diabetic retinopathy. Possible correlations between messenger ribonucleic acid (mRNA) levels of these genes were also identified.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06
• Status Verified: 2013-09
• Primary Completion: 2013-09
• Study First Submitted: 2013-09-16
• Study First Submitted QC: 2013-09-18
• Last Update Submitted: 2013-09-18
• Study First Posted: 2013-09-19
• Last Update Posted: 2013-09-19
• Study Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Caucasian race,
• both males and females,
• aged ≥ 55 years,
• suffering from idiopathic ERMs or secondary ERMs in proliferative diabetic retinopathy (PDR).
• Presence of ERM was proven in optical coherence tomography (OCT) examination.

Exclusion criteria:

• aged < 55 years,
• systemic connective tissue disease,
• active inflammatory process

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gene expression in patients with idiopathic and secondary epiretinal membranes in proliferative diabetic retinopathy.	The period between the diagnosis of the ERMs and the actual surgery for the condition was between 2 and 43 months.

Trial Locations

Locations (1)

Medical University of Silesia; 🇵🇱 Katowice, Poland