A comparative study of efficacy of Therapeutic Ultrasound therapy and Intralesional Injection in patients with oral submucous fibrosis - a clinical trial study

The goal of this study is to assess the effects of intralesional injection of dexamethasone, hyaluronidase and adjuvant therapeutic ultrasonography with physical therapy and in the treatment of persons with oral submucous fibrosis. To assess the effectiveness of intralesional injection and ultrasound therapy in patients with oral submucous fibrosis. Thirty patients selected who met the inclusion criteria with all age group and clinically diagnosed with oral submucous fibrosis were included in the study. Exclusions from the study were patients having a history of radiation therapy, OSMF medication or surgery, systemic sclerosis, tetany, or other systemic diseases. Prior to the study’s commencement, institutional ethical committee approval was acquired. Every participant in this study provided written informed permission. After meeting the inclusion and exclusion criteria, the patients who were chosen for the study were divided into groups A and B based on the sequence created by the software. Fifteen OSMF patients in Group A received injections  of dexamethasone (4 mg/ml) and 1500 IU of hyaluronidase. Group B comprises 15 OSMF patients who received physical activity and therapeutic ultrasound treatment. Patients will have intralesional injections and ultrasound therapy application every two weeks for a total of four weeks. Areas for submucosal local injection include the buccal mucosa, pterygomandibular raphae, outer soft palate, and any circumoral bands. Dexamethasone (4 mg/ml) and 1500 IU of hyaluronidase injection. All of the patients received treatment using the same calibrated ultrasound equipment throughout the research [Figure  Regarding the ultrasound therapy procedure, ultrasound at a continuous 1:1 duty cycle intensity of 1.5 to 1.8 W/cm2 ,3 MHz for 5–6 minutes while moving a sound head back and forth in the template at a pace of around 4 cm/s to each side over the fibrosis area.