Effects of Intraoperative Esmolol on Post-mastectomy Pain Syndrome: a Cross-sectional Study
试验速览
- 阶段
- 不适用
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Incidence of post-mastectomy chronic pain syndrome
研究概览
简要总结
Chronic postoperative pain is an entity that is usually neglected by anesthetists, but several studies show that the choice of anesthetic technique may interfere with this prevalence. Esmolol is a selective beta-blocker of ultra fast duration that has been studied as a perioperative venous adjuvant with antihyperalgesic and opioid sparing action. The investigators ventured the possibility of this anti-hyperalgesic effect attenuating the chronic pain syndrome post-mastectomy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients previously submitted to the study Analgesic Effect of Intraoperative Esmolol in Mastectomies: a randomized placebo controlled trial
排除标准
- •Patient aged less than 18 years and over 65 years;
- •Patients who refuse to participate in the study;
- •Patients with pulmonary disease;
- •Patients with cardiac, renal or hepatic disease;
- •Use of psychoactive drug;
- •Patients with sinus bradycardia;
- •Pregnant women;
- •Patients with allergy to dipyrone, morphine;
- •Patients with chronic pain prior to the surgical procedure;
- •Patients with neurological disorders;
- •Patients undergoing surgical resurfacing
研究组 & 干预措施
Control
Patients who underwent mastectomy under standard general anesthesia
Patients in placebo group received general balanced inhaled anesthesia with sevoflurane and remifentanil and a saline 0,9% infusion pump.
干预措施: Control (Drug)
Esmolol
Patients in esmolol group received general balanced inhaled anesthesia with sevoflurane and a bolus infection of esmolol 500 mgc/kg followed by a continuous infusion of esmolol 100 mcg/kg/min
干预措施: Esmolol (Drug)
结局指标
主要结局
Incidence of post-mastectomy chronic pain syndrome
时间窗: Through study completion, an average of 6 to 9 month
Incidence analysis using a questionnaire applied to patients in the late postoperative period.
次要结局
- Stratify the possible types of pain(Through study completion, an average of 6 to 9 month)
- Assess the intensity of pain: Pain Scores on the Visual Analog Scale(Through study completion, an average of 6 to 9 month)
- Identify possible risk factors(Through study completion, an average of 6 to 9 month)
研究者
Fabricio Tavares Mendonca
Preceptor correspondent for anesthesiology residency
Hospital de Base