Mortality Score in Elderly Patients With Colon Cancer

Completed

• Conditions: Colon Cancer; Mortality; Surgery

• Registration Number: NCT04538404
• Lead Sponsor: University of Bologna

Brief Summary

CR-POSSUM is one of the most used surgical scores to predict mortality after colorectal surgery. Its main drawback is the requirement of intraoperative variables, whose collection is time-consuming and prevents from obtaining a purely preoperative risk assessment. The primary aim of the study is to develop a new surgical score using preoperative parameters to predict 30-day mortality after colon cancer surgery in the elderly population. The secondary objective is to analyze its efficacy compared to CR-POSSUM.

Detailed Description

Patients aged 80 and older undergoing surgery for colon cancer from 2011 to 2017 in an Italian hospital were retrospectively selected. MECC score \[Mortality in Elderly patients with Colon Cancer\] was calculated summing up the scores relating to: arterial saturation of O2, Systolic Blood Pressure, Heart Rate, WBCs, Albumin, Creatinine. Once CR-POSSUM was calculated, the two scores were compared.

Study Timeline

• Study Start: 2011-01-01
• Primary Completion: 2017-08-31
• Study Completion: 2019-01-31
• Status Verified: 2020-08
• Study First Submitted: 2020-08-22
• Study First Submitted QC: 2020-09-03
• Last Update Submitted: 2020-09-03
• Study First Posted: 2020-09-04
• Last Update Posted: 2020-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 385

Inclusion Criteria

• Patients aged 80 and above having elective and emergency colonic resection for colon cancer via open, laparoscopic and converted approaches

Exclusion Criteria

• Surgical resections for rectal cancer and surgical procedures for non-neoplastic colon pathologies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
New surgical score using preoperative parameters to predict 30-day mortality after colon cancer surgery in the elderly population	Up to 30 days after surgery	MEC Score (arterial saturation of O2, Systolic Blood Pressure, Heart Rate, WBCs, Albumin, Creatinine) for the evaluation of the risk of in-hospital mortality occurred during hospitalization up to 30 days

Trial Locations

Locations (2)

Marialuisa Lugaresi; 🇮🇹 Bologna, Italy

Bruno Nardo; 🇮🇹 Bologna, Italy