Effects of Calorie Restriction on Accumulation of Old, Modified Proteins in Abdominally Obese Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- Change in muscle protein synthesis from baseline to 16 weeks
研究概览
简要总结
This study is being done to understand the effects of calorie restriction and weight loss on muscle protein metabolism in adult men and women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI will be between 30 kg/m2 - 38 kg/m2 and waist circumference for women ≥ 88 cm and men ≥ 104 cm
- •Age 45 to 65 years.
- •Male and Female
排除标准
- •Active coronary artery disease
- •BMI < 30 kg/m2 Participation in structured exercise (>2 times per week for 30 minutes or longer)
- •Medications known to affect muscle metabolism (beta blockers)
- •Renal failure (serum creatinine > 1.5mg/dl)
- •Chronic active liver disease (AST and ALT > 3 times normal)
- •Fasting blood glucose > 126 mg/dl
- •Anti-coagulant therapy (warfarin/heparin)
研究组 & 干预措施
Calorie restriction
Participants will work with the CRU dietetics staff to plan a diet that will result in their losing 1-2 pounds per week over 16 weeks.
干预措施: Calorie Restriction (Behavioral)
Control
Participants will continue their normal living for entire time of the study, totaling 16 weeks.
干预措施: Control (normal living) (Behavioral)
结局指标
主要结局
Change in muscle protein synthesis from baseline to 16 weeks
时间窗: Measured at week 0 (baseline) and week 16
The investigators will determine the rate of incorporation of stable isotope amino acid tracers in skeletal muscle protein on average resting muscle protein synthesis rate (% new muscle protein per hour) and will be performed at baseline and 16 weeks after caloric restriction or control diet.
次要结局
- Change in insulin sensitivity from 0 (baseline) and 16 weeks(Measured at week 0 (baseline) and week 16)
研究者
K. Sreekumaran Nair
Professor of Medicine
Mayo Clinic