Carotid Artery Corrected Flow Time as a Predictor of Hypotension After Induction of General Anesthesia in Elderly Patients

Completed

• Conditions: General Anesthesia Induction for Elective Surgery
• Interventions: Procedure: ultrasonographic measurement of carotid artery corrected flow time (FTc)

• Registration Number: NCT05628051
• Lead Sponsor: Fujian Medical University Union Hospital

Brief Summary

The number of elderly patients undergoing elective surgery has been growing in recent years. Elderly patients often have a variety of underlying diseases, including hypertension, coronary heart disease, diabetes, arteriosclerosis, etc., which increase the risk. When the elderly receive general anesthesia, hypotension often occurs after anesthesia induction. Once hypotension occurs, it may lead to myocardial ischemia, myocardial infarction, stroke and other serious complications. Therefore, in clinical anesthesia, a simple, quick and accurate prediction method is needed to evaluate and predict the risk of hypotension in elderly patients after induction, so that appropriate intervention measures can be taken in advance to reduce the incidence of hypotension in elderly patients after induction, thus reducing the occurrence of related complications and ensuring the safety of anesthesia and surgery.Carotid Artery Corrected Flow Time（FTc） is a recently developed volumetric predictor, which refers to the time between the the onset of systolic flow until the closure of the aortic valve. It is related to cardiac preload and can reflect cardiac output to a certain extent. It is considered as a reliable indicator for evaluating volume status and volumetric reactivity. Therefore, this study assessed the effect of FTc combined with perioperative fluid therapy on preventing hypotension after general anesthesia induction in elderly patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-01
• Study First Submitted: 2022-11-17
• Study First Submitted QC: 2022-11-17
• Study First Posted: 2022-11-28
• Primary Completion: 2022-12-30
• Study Completion: 2023-03-01
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-30
• Last Update Posted: 2023-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 177

Inclusion Criteria

• patients who received elective surgery under general anesthesia, aged 65-85 years old, gender unlimited, ASAI-II

Exclusion Criteria

• uncontrolled hypertension
• unstable angina pectoris
• history of myocardial infarction
• after heart stent implantation
• severe arrhythmia：Atrial fibrillation、Ventricular premature beat, frequent atrial premature beat, other non-sinus rhythm
• pacemaker implants
• cardiomyopathy
• a left ventricular ejection fraction of < 40%
• history of neck trauma and surgery
• BMI>30

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-hypotension after anesthetic induction group	ultrasonographic measurement of carotid artery corrected flow time (FTc)	Patients without hypotension after anesthetic induction
Hypotension after anesthetic induction group	ultrasonographic measurement of carotid artery corrected flow time (FTc)	Patients with hypotension after anesthetic induction

Primary Outcome Measures

Name	Time	Method
Carotid artery corrected flow time (FTc)	5 minutes before induction of general anesthesia	the area under the receiver operating characteristics curve of corrected flow time in carotid artery measured by ultrasonography to predict hypotension after anesthetic induction

Trial Locations

Locations (1)

Fujian Medical University Union Hospital; 🇨🇳 Fuzhou, Fujian, China