Application of New Magnetic Resonance UTE Technique in Hip Joint Lesions

Recruiting

• Conditions: Hip Disease

• Registration Number: NCT05998720
• Lead Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University

Brief Summary

Explore the imaging and quantitative monitoring of hip bone, cartilage and ligament by magnetic resonance UTE technology, combined with QCT and DXA technology, to provide a more accurate basis for clinical evaluation and treatment.

Detailed Description

Osteoporosis is a systemic bone metabolism-related disease characterized by decreased bone mass per unit volume, increased bone fragility, decreased bone density, thinning of the bone cortex and changes in bone microstructure. It often occurs in the lumbar spine and hip joint. Femoral neck fracture is a common complication of hip osteoporosis, which seriously affects people's quality of life. UTE technology can clearly image and quantify human cortical bone and cancellous bone, and advanced UTE technology such as STAIR-UTE and UTE-MT have made some progress in the field of osteoporosis. The purpose of this study was to explore UTE technology for imaging and quantitative study of cortical bone, cancellous bone and cartilage of hip joint, and to find more accurate imaging methods for clinical evaluation of hip osteoporosis and other diseases.

Study Timeline

• Study Start: 2023-07-01
• Status Verified: 2023-08
• Study First Submitted: 2023-08-02
• Study First Submitted QC: 2023-08-17
• Last Update Submitted: 2023-08-17
• Study First Posted: 2023-08-21
• Last Update Posted: 2023-08-21
• Primary Completion: 2024-06-13
• Study Completion: 2024-06-13

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. Patients with past or suspected osteoporosis and bone loss;
2. Patients with previous femoral neck fracture;
3. Patients with avascular necrosis of femoral head;
4. Hip osteoarthritis patients.

Exclusion Criteria

1. Patients with metal implants in corresponding parts;
2. Claustrophobic.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Magnetization Transfer Ratio (MTR)	Baseline (before surgery)	magnetization transfer ratio
T2 relaxation rate	Baseline (before surgery)	R2\*
proton density fat fraction (PDFF)	Baseline (before surgery)	Magnetic resonance proton density fat fraction
T1rho	Baseline (before surgery)	spin-lattice relaxation in the rotation ame

Secondary Outcome Measures

Name	Time	Method
Subjective rating values	Baseline (before surgery)	rating values

Trial Locations

Locations (1)

Radiography department; 🇨🇳 Zhuhai, Guangdong, China