Application of New Magnetic Resonance Technique-UTE in Hip Joint Lesions
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Magnetization Transfer Ratio (MTR)
研究概览
简要总结
Explore the imaging and quantitative monitoring of hip bone, cartilage and ligament by magnetic resonance UTE technology, combined with QCT and DXA technology, to provide a more accurate basis for clinical evaluation and treatment.
详细描述
Osteoporosis is a systemic bone metabolism-related disease characterized by decreased bone mass per unit volume, increased bone fragility, decreased bone density, thinning of the bone cortex and changes in bone microstructure. It often occurs in the lumbar spine and hip joint. Femoral neck fracture is a common complication of hip osteoporosis, which seriously affects people's quality of life. UTE technology can clearly image and quantify human cortical bone and cancellous bone, and advanced UTE technology such as STAIR-UTE and UTE-MT have made some progress in the field of osteoporosis. The purpose of this study was to explore UTE technology for imaging and quantitative study of cortical bone, cancellous bone and cartilage of hip joint, and to find more accurate imaging methods for clinical evaluation of hip osteoporosis and other diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with past or suspected osteoporosis and bone loss;
- •Patients with previous femoral neck fracture;
- •Patients with avascular necrosis of femoral head;
- •Hip osteoarthritis patients.
排除标准
- •Patients with metal implants in corresponding parts;
- •Claustrophobic.
结局指标
主要结局
Magnetization Transfer Ratio (MTR)
时间窗: Baseline (before surgery)
magnetization transfer ratio
T2 relaxation rate
时间窗: Baseline (before surgery)
R2\*
proton density fat fraction (PDFF)
时间窗: Baseline (before surgery)
Magnetic resonance proton density fat fraction
T1rho
时间窗: Baseline (before surgery)
spin-lattice relaxation in the rotation ame
次要结局
- Subjective rating values(Baseline (before surgery))
