跳至主要内容
临床试验/NCT05998720
NCT05998720招募中不适用

Application of New Magnetic Resonance Technique-UTE in Hip Joint Lesions

Fifth Affiliated Hospital, Sun Yat-Sen University1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2023年7月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
150
试验地点
1
主要终点
Magnetization Transfer Ratio (MTR)

研究概览

简要总结

Explore the imaging and quantitative monitoring of hip bone, cartilage and ligament by magnetic resonance UTE technology, combined with QCT and DXA technology, to provide a more accurate basis for clinical evaluation and treatment.

详细描述

Osteoporosis is a systemic bone metabolism-related disease characterized by decreased bone mass per unit volume, increased bone fragility, decreased bone density, thinning of the bone cortex and changes in bone microstructure. It often occurs in the lumbar spine and hip joint. Femoral neck fracture is a common complication of hip osteoporosis, which seriously affects people's quality of life. UTE technology can clearly image and quantify human cortical bone and cancellous bone, and advanced UTE technology such as STAIR-UTE and UTE-MT have made some progress in the field of osteoporosis. The purpose of this study was to explore UTE technology for imaging and quantitative study of cortical bone, cancellous bone and cartilage of hip joint, and to find more accurate imaging methods for clinical evaluation of hip osteoporosis and other diseases.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Patients with past or suspected osteoporosis and bone loss;
  • Patients with previous femoral neck fracture;
  • Patients with avascular necrosis of femoral head;
  • Hip osteoarthritis patients.

排除标准

  • Patients with metal implants in corresponding parts;
  • Claustrophobic.

结局指标

主要结局

Magnetization Transfer Ratio (MTR)

时间窗: Baseline (before surgery)

magnetization transfer ratio

T2 relaxation rate

时间窗: Baseline (before surgery)

R2\*

proton density fat fraction (PDFF)

时间窗: Baseline (before surgery)

Magnetic resonance proton density fat fraction

T1rho

时间窗: Baseline (before surgery)

spin-lattice relaxation in the rotation ame

次要结局

  • Subjective rating values(Baseline (before surgery))

研究者

发起方
Fifth Affiliated Hospital, Sun Yat-Sen University
申办方类型
Other
责任方
Sponsor

研究点 (1)

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