The difference of infant's gut microbiome between cesarean delivery and vaginal delivery
- Conditions
- Infant gut microbiomemicrobiome, gut, infant, cesarean, vaginal delivery
- Registration Number
- TCTR20221024003
- Lead Sponsor
- Strategic Wisdom and Research Institute, Srinakharinwirot University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 280
1. Term healthy newborn with normal vital signs and physical examination. 2. Delivered at HRH Maha Chakri Sirindhorn Medical Center, Faculty of Medicine, Srinakharinwirot University, Thaialnd. 3. Delivered from pregnant women with no infection history. 4. Delivered from pregnant women not received antibiotic treatment except for Cesarean empirical antibiotic prophylaxis.
1. Infant's fecal specimen cannot be corrected within 48 hours after delivery
2. Infant diagnosed with gastrointestinal abnormalities, other structural abnormalities or genetic disease after delivery.
3. Infant diagnosed with complications after delivery e.g., jaundice that need phototherapy or exchanged transfusion, early neonatal sepsis
4. Infant received antibiotic within 48-72 hours after delivery before collecting the fecal specimen.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Alpha diversity After complete sample collection QIMME,Difference of gut microbiomes After complete sample collection Non-parametric t-test
- Secondary Outcome Measures
Name Time Method Gravida 1 year Record form,Parity 1 year Record form,Abortion 1 year Record form,Gestational age 1 year Record form,Ethnic 1 year Record form,Income 1 year Record form,Religion 1 year Record form,BMI 1 year Record form,ANC risk 1 year Record form,Medications 1 years Record form,Underlying disease 1 year Record form,Route of delivery 1 year Record form,Intrapartum complications 1 year Record form,Postpartum complications 1 year Record form,Infant sex 1 year Record form,Birth body weight 1 year Record form,APGAR score 1 year Record form