Effect of Exercise on GDF-15 Levels in Prediabetic Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Level of Growth Diferantiation Factor-15
研究概览
简要总结
The aim of this study is to evaluate whether there is a change in GDF-15 levels in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program with guide-based exercise programs.
详细描述
GDF-15, which has anorexigenic effects, increases with exercise. In prediabetic patients, GDF-15 is higher than healthy controls. The effect of exercise on GDF-15 levels in prediabetic patients is unknown.
The aim of this study is to evaluate whether there is a change in GDF-15 levels after the application of guideline-based exercise programs in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Body mass index 30-34.9 kg / m2
- •Sedentary life-style (Physical activity below 300 kcal / day will be assessed by Minnesota Leisure Physical Activity Questionnaire)
- •Those who have sufficient motivation to participate in the exercise program (will be evaluated by face-to-face interview by the researchers)
- •Having the same weight for 6 months before participating in the study (± 2.5 kg)
- •Those diagnosed with prediabetes by oral glucose tolerance test and / or HbA1c measurement will be included.
排除标准
- •Serious medical condition (e.g. advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.)
- •Having cardiovascular disease
- •Having diabetes
- •Using metformin
- •Taking hormone replacement therapy
- •less than 1 year life expectancy
- •HIV positivity
- •Substance use
- •Functional dependence
- •Cognitive weakness
- •Those with other diseases that will affect the study result (respiratory diseases, muscle diseases, etc.)
- •Those who use drugs or supplements that will affect the results of the study
研究组 & 干预措施
İntevention group
Prediabetic patients with age 30-50 and overweight Standart recommendations Exercise intervention will be made.
干预措施: Exercise (Behavioral)
Control group
Prediabetic patients with age 30-50 and overweight Only Standart recommendations
Metformin Group
Prediabetic patients who received metformin Standart recommendations
结局指标
主要结局
Level of Growth Diferantiation Factor-15
时间窗: 12 weeks
Level of Growth Diferantiation Factor-15
次要结局
- Level of VO2max(12 weeks)
研究者
Elif Yıldırım Ayaz
Principal Investigator
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey