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Clinical Trials/NCT06227052
NCT06227052
Completed
Phase 4

Vapocoolant Application for Pain Reduction During Office-based Gynecologic Procedures: a Randomized Controlled Trial (VAPOR)

Queen's Medical Center1 site in 1 country98 target enrollmentFebruary 5, 2024

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Pain With Paracervical Block
Sponsor
Queen's Medical Center
Enrollment
98
Locations
1
Primary Endpoint
Pain With Paracervical Block
Status
Completed
Last Updated
7 months ago

Overview

Brief Summary

The purpose of this study is to assess if Num vapocoolant spray decreases pain associated with paracervical block in gynecology procedures.

Detailed Description

After patients seen in our clinic have decided to proceed with a gynecology procedure that requires a paracervical block, the doctor will evaluate if the patient meets eligibility criteria for this study. If the patient does meet eligibility criteria, the doctor will inform the patient about the study and the potential risks. All patients will be given written informed consent. If the patient decides to participate in the study, they will be randomized (patient blinded) to receive either Num vapocoolant spray or placebo (normal saline spray), which the patient will receive during their gynecologic procedure just before the paracervical block. The purpose of this study is to see if the Num vapocoolant spray decreases patients pain with the paracervical block.

Registry
clinicaltrials.gov
Start Date
February 5, 2024
End Date
March 7, 2025
Last Updated
7 months ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Sponsor
Queen's Medical Center
Responsible Party
Principal Investigator
Principal Investigator

Catherine Rault

Complex Family Planning Fellow

Queen's Medical Center

Eligibility Criteria

Inclusion Criteria

  • Age 18 years of age or older
  • Undergoing a procedure requiring paracervical block
  • English-speaking
  • Able and willing to sign the informed consent form and agree to terms of the study

Exclusion Criteria

  • Required or requested narcotics, anxiolytics, IV sedation, or general anesthesia for the procedure
  • Declines or has a contraindication/allergy to ibuprofen
  • Previously received vapocoolant spray in a medical setting
  • Contraindications or allergies to lidocaine for paracervical block or vapocoolant spray components (1,1,3,3-pentafluoropropaine or 1,1,1,2-tetrafluroethane)

Outcomes

Primary Outcomes

Pain With Paracervical Block

Time Frame: Immediately after paracervical block (0 minutes after PCB completed)

The investigators will ask patients to rate their pain with the paracervical block using a visual analog scale (VAS). The visual analog scale is 100 mm line, with values 0 to 100. 0 is marked as no pain, 100 is marked as worst pain.

Secondary Outcomes

  • Other Pain Points During Gynecology Procedure(Baseline pain (immediately before procedure), after tenaculum (0 minutes after tenaculum placed), and 5 minutes after procedure)
  • Patient Satisfaction With Procedure(Immediately after their gynecologic procedure (0 minutes after procedure completed))
  • Provider Ease of Use(Within 5 minutes after patient procedure)
  • Pre Procedure Anxiety(Immediately after enrollment - before procedure)

Study Sites (1)

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