Effect of crocin on ocular complications of Behcet's disease

Phase 2

Recruiting

• Conditions: Behcet's Disease.; Behcet's disease; M35.2

• Registration Number: IRCT20130418013058N12
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

A patient with active Behcet's with ocular complications is selected according to the sun criteria,
Patients with Behcet's syndrome with anterior, posterior, or diffuse eye involvement
Long-term illness of the eye with active retinal vasculitis and macular edema
Age over 18 years of both sexes
A patient with Behcet's who is resistant (without improvement or exacerbation of the eye disease) or an approximate response (mild to moderate) to combination therapy (Psychosis and Steroids drugs)
The ability to understand the overall study, interventions and possible complications

Exclusion Criteria

Patients with bilateral vision loss
Patients receiving anti-TNF drugs such as thalidomide and pentoxifylline in the past three months.
Patients with a history of immunosuppression include a viral infection such as tuberculosis
Severe viral infections including hepatitis, pneumonia, pyelonephritis, or hepatitis in the last three months
Pregnancy and breastfeeding
Sensitivity to saffron
alcohol consumption
Cataract and other general items
Diabetes

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ocular Inflammation. Timepoint: Before Intervention, and after three months. Method of measurement: Fluorescein Angiography.

Secondary Outcome Measures

Name	Time	Method
Best Corrected Visual Acuity. Timepoint: Before Intervention, and After Three Months. Method of measurement: Snellen Chart.