Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children
Not Applicable
- Conditions
- Acute Severe Asthma
- Interventions
- Drug: 50% magnesium sulphateDrug: isotonic magnesium sulphate
- Registration Number
- NCT02112305
- Lead Sponsor
- Queen Sirikit National Institute of Child Health
- Brief Summary
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
- Detailed Description
Intervention: At randomization eligible patients were allocated to receive 2.5ml of isotonic magnesium sulphate (150 mg,245 mmol/L) on three occasional at 20 minutes interval or standard treatment 50 mg/kg intravenous magnesium sulphate. The asthma severity score was record at 0,20,40,60,120,180,240 minutes post randomization. Adverse event were assessed at each assessment point. Patients were followed up until discharge from hospital to collect secondary outcome data.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Children age 2-15 years presenting with severe asthma or persistent wheeze without responding to conventional therapy
Exclusion Criteria
- chronic lung disease
- history of adverse reaction form magnesium sulphate
- life threatening condition
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 50% magnesium sulphate 50% magnesium sulphate magnesium sulphate 50mg/kg/dose intravenous drip in 20 minutes for one dose isotonic magnesium sulphate isotonic magnesium sulphate 2.5 ml of isotonic magnesium sulphate (150 mg, 245 mmol/L) on three occasional at 20 minutes interval
- Primary Outcome Measures
Name Time Method Asthma severity score 60 minute
- Secondary Outcome Measures
Name Time Method Length of stay in the hospital within 2 weeks
Trial Locations
- Locations (1)
Queen Sirikit National Institute of Child Health
🇹ðŸ‡Bangkok, Thailand