Assesment of topical dexmedetomidine administration on intraoperative bleeding during functional endoscopic sinus surgery
Phase 2
- Conditions
- Chronic rhinosinusitis.Chronic pansinusitisJ32.4
- Registration Number
- IRCT20100126003186N12
- Lead Sponsor
- Hamedan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
Patients with chronic rhinosinusitis with or without polyposis candidate for FESS surgery
Age between 18 and 60 years
Lack of history of bleeding disorders such as hemophilia and ... and the disruptions of coagulation tests (PT, PTT, INR, BT, CT and platelet counts)
Exclusion Criteria
Allergy to dexmedetomidine
Detection of complications during surgery or anesthesia requiring special action
Patients with sinonasal tumors
history of thromboembolic events
history of acute or chronic renal failure
take of anti-coagulant drugs for up to five days before surgery
hepatic cirrhosis
systemic diseases such as hypertension, diabetes, heart failure, cardiac rhythm disorders, and coronary artery disease
pregnancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quality of surgical field. Timepoint: 15th, 30th, 60th and 90th minutes after surgery. Method of measurement: The quality of vision of surgical field was measured based on Boezaart Grading.;Amount of bleeding during surgery. Timepoint: 15th, 30th, 60th and 90th minutes after surgery. Method of measurement: the amount of intraoperative bleeding, based on the amount of blood collected in the bottle of suction will be estimated.
- Secondary Outcome Measures
Name Time Method The amount of pain. Timepoint: 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;Median arterial pressure. Timepoint: 15th, 30th, 60th and 90th minutes after surgery. Method of measurement: using automated sphygmomanometer.