The Link Between Omnivorous, Vegan, Vegetarian, Low Carb Diets and Health Indicators in Healthy Subjects With Normal Weight
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Changes in systemic inflammation
研究概览
简要总结
The cohort study investigates the effect of different dietary intake among omnivorous, vegan, vegetarian and low-carb diets on health parameters and on long-term overall health. The participants blood parameters, dietary intake, gut microbiota composition, body mass and composition, resting energy expenditure, lifestyle factors and psychological factors will be determined and measured.
详细描述
Vegetarian and vegan diets have been shown to have health benefits on preventing cardiovascular diseases, type 2 diabetes and cancer. They are both gaining popularity in public. Ketogenic diet has also been very popular, especially due to its effect on weight loss and blood glucose parameters. To our knowledge there, are no studies that compare long-term effects of all three diets and omnivorous diets with regards to health parameters and gut microbiota composition.
The aim of the proposed study is to investigate the link between different diets and health parameters, such as parameters related to longevity, inflammation, stress and gut microbiota composition. The study is designed to compare different diets and their relationship with the body as a whole.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18,5 < BMI < 30 kg/m2
- •asymptomatic for any disease
- •medication free
- •same pattern of eating in the last 3 months
- •stable body mass in the last 3 months
排除标准
- •BMI < 18,5 and > 30 kg/m2
- •presence of any chronic disease
- •taking any medications
- •changed eating pattern in the last 3 months
- •unstable body mass in the last 3 months
- •taking antibiotics in the last 3 months
结局指标
主要结局
Changes in systemic inflammation
时间窗: Change from baseline at 5 years.
CRP \[mg/L\] will be measured as a marker of inflammation.
Changes in serum total antioxidative capacity
时间窗: Change from baseline at 5 years.
Total antioxidative capacity of serum will be measured with Photochem instrument and expressed as nanomole equivalents of ascorbic acid per microliter of serum.
次要结局
- Changes in gut microbiota composition(Change from baseline at 5 years.)
- Changes in autophagy(Change from baseline at 5 years.)
- Changes in grip strength(Change from baseline at 5 years.)
- Changes in micronutrient intake(Change from baseline at 5 years.)
- Changes in lifestyle factors(Change from baseline at 5 years.)
- Changes in macronutrient intake(Change from baseline at 5 years.)
- Changes in body composition(Change from baseline at 5 years.)
- Changes in resting metabolic rate(Change from baseline at 5 years.)
- Changes in anxiety(Change from baseline at 5 years.)
- Changes in body satisfaction(Change from baseline at 5 years.)
研究者
Zala Jenko Praznikar
associate professor
University of Primorska