Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis

Completed

• Conditions: Chronic Periodontitis (Disorder)
• Interventions: Diagnostic Test: serum lipid levels and Lp-PLA2

• Registration Number: NCT03041480
• Lead Sponsor: Meenakshi Ammal Dental College and Hospital

Brief Summary

To assess the association between periodontal parameters, serum lipid profile and Lp-PLA2 level in systemically healthy Chronic Periodontitis subjects and healthy controls.

Detailed Description

Seventy five participants were divided into 3 groups. The groups consisted of GROUP I- generalized severe chronic periodontitis, GROUP II- generalized moderate chronic periodontitis and GROUP III- systemically and periodontally healthy volunteers who served as control. The selected patients were then evaluated for periodontal parameters, lipid profile and Lp-PLA2.

Study Timeline

• Study Start: 2015-02-02
• Primary Completion: 2015-08-23
• Study Completion: 2015-11-26
• Status Verified: 2017-01
• Study First Submitted: 2017-02-01
• Study First Submitted QC: 2017-02-01
• Last Update Submitted: 2017-02-01
• Study First Posted: 2017-02-02
• Last Update Posted: 2017-02-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Group I:

1. Subjects with age ≥ 35 years.
2. Presence of at least 24 teeth, with Clinical attachment loss (CAL) ≥ 5mm in more than 30% of sites.

Group II:

1. Subjects with age ≥ 35 years.
2. Presence of at least 24 teeth, with Clinical attachment loss (CAL) between 3-4 mm in more than 30% of sites.

Group III:

1. Subjects with age ≥ 35 years.
2. Healthy and intact periodontium

Exclusion Criteria

1. Presence of any systemic disease or conditions that could affect periodontal tissues.
2. History of periodontal treatment in past 6 months.
3. Smoking and alcoholism
4. Anomalies of blood and immune system
5. Systemic medication or antibiotic treatment for the previous 6 months.
6. Pregnant females.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
GROUP II	serum lipid levels and Lp-PLA2	Estimation of serum lipid levels and Lp-PLA2 in generalized moderate chronic periodontitis
GROUP I	serum lipid levels and Lp-PLA2	Estimation of serum lipid levels and Lp-PLA2 in generalized severe chronic periodontitis
GROUP III	serum lipid levels and Lp-PLA2	Estimation of serum lipid levels and Lp-PLA2 in systemically and periodontally healthy controls

Primary Outcome Measures

Name	Time	Method
Estimation of serum Lp-PLA2	9 months	Serum Lp-PLA2 was estimated in all the groups using ELISA

Secondary Outcome Measures

Name	Time	Method
Estimation of serum lipid profile	9 months	Serum Total cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein and very low density lipoprotein