Skip to main content
MedPathMedPath Home
Clinical Trials/ISRCTN87408408
ISRCTN87408408
Completed
Not Applicable

Molecular profiling of post-menopausal women with breast cancer on Neoadjuvant Endocrine Therapy with tamoxifen or exemestane

Cambridge University Hospitals NHS Trust (UK)0 sites100 target enrollmentJanuary 26, 2007
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
Conditionsocalised or locally advanced early breast cancerCancerBreast cancer

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
ocalised or locally advanced early breast cancer
Sponsor
Cambridge University Hospitals NHS Trust (UK)
Enrollment
100
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
January 26, 2007
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
Female

Investigators

Sponsor
Cambridge University Hospitals NHS Trust (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Women with histological diagnosis of primary invasive breast cancer on core biopsy
  • •2\. Not a candidate for chemotherapy
  • •3\. Localised or locally advanced breast cancer
  • •4\. Ultrasound size at least 2 cm:
  • •a. unifocal tumour:
  • •i. T2 or T3 tumours (radiological size more than 20 mm)
  • •ii. T4 tumour of any size with direct extension to either chest wall or skin
  • •iii. inflammatory carcinoma with tumour of any size
  • •b. other locally advanced disease:
  • •i. clinical and radiological involvement of axillary lymph node (radiological diameter more than 20 mm) and primary breast tumour of any diameter

Exclusion Criteria

  • •1\. Patient unfit to receive endocrine\-based therapy
  • •2\. Previous history of cancer excluding basal cell carcinoma, cervical carcinoma in\-situ, or ductal carcinoma in situ of the breast
  • •3\. Previous deep vein thrombosis or pulmonary embolism

Outcomes

Primary Outcomes

Not specified

Similar Trials

Active, not recruiting
Phase 1
Molecular profiling of postmenopausal women with breast cancer on neoadjuvant exemestane or tamoxifeEarly or locally advanced breast cancerTherapeutic area: Diseases [C] - Cancer [C04]
EUCTR2005-001698-89-GBCambridge University Hospitals NHS Foundation Trust26
Recruiting
Phase 4
A pilot study to assess bone mineral density (BMD) by digital X­ray radiogrammetry (DXR) in women undergoing mammography, and comparison with BMD by dual energy X­ray absorptiometry (DXA)OsteoporosisMusculoskeletal - Osteoporosis
ACTRN12614001230640Breast Cancer Institute (Westmead Hospital)200
Completed
Phase 3
Study of the Molecular Features of Postmenopausal Women With HR+ HER2-negative aBC on First-line Treatment With Ribociclib and Letrozole and, in Patients With a PIK3CA Mutation, on Second-line Treatment With Alpelisib Plus FulvestrantBreast Cancer
NCT03439046Novartis Pharmaceuticals287
Completed
Phase 3
IBCSG 35-07 / BIG 1-07 : Study of Letrozole Extension (SOLE). Letrozole in Preventing the Return of Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer.Endocrine Responsive Breast CancerCancer - Breast
ACTRN12608000243314ovartis Pharma AG4,800
Recruiting
Not Applicable
A randomised cross-over trial to examine the effects of calcium citrate on blood calcium levels, blood coagulation and blood pressure in normal postmenopausal womeCardiovascular diseaseDiet and Nutrition - Other diet and nutrition disordersCardiovascular - HypertensionCardiovascular - Diseases of the vasculature and circulation including the lymphatic system
ACTRN12614000865617niversity of Auckland40