ACTRN12615000129583招募中不适用
Does intravenous (IV) levetiracetam or IV phenytoin terminate seizures better when used as a second line treatment for the emergency management of convulsive status epilepticus (CSE) in children.
Starship Children's Hospital0 个研究点目标入组 200 人开始时间: 2015年2月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 3 Months 至 16 Years（—）
- 性别
- All
入选标准
- •1.Children aged between 3 months and 16 years;
- •CSE is defined clinically as a child who is unresponsive with continuing abnormality of movement (increased tone or jerking) of greater than five minutes duration, or two or more recurrent convulsions without recovery of conscious between convulsions, or three or more convulsions within the proceeding hour, and currently experiencing a convulsion. This definition encompasses the International League Against Epilepsy (ILAE) seizure types of generalised tonic-clonic convulsions, secondarily generalised tonic-clonic convulsions, and complex partial status epilepticus, but not absence, myoclonic, tonic and simple partial status epilepticus.
排除标准
- •1.Pregnancy;
- •2.Known contraindication or allergy to levetiracetam or phenytoin;
- •3.Major head injury;
- •4.Previous administration of second line anticonvulsants prior to ED arrival;
- •5.Current levetiracetam or phenytoin use;
- •6.Prior enrolment in the research;
- •7.Specific CSE management plan stating refractory to phenytoin.
研究者
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