Wound-healing Improvement by Resurfacing Split-Thickness Skin Donor Sites With Thin Split-thickness Grafting

Completed

• Conditions: Skin Graft Disorder; Disorder of Skin Donor Site; Wound Healing Disturbance of
• Interventions: Procedure: covered with the occlusive hydrocellular dressing; Procedure: covered with paraffin gauze; Procedure: regrafted with thin split-thickness skin graft

• Registration Number: NCT01974583
• Lead Sponsor: Tang-Du Hospital

Brief Summary

Split-thickness skin grafting remains fundamental treatment of patients with deep burns and other traumatic injuries. However, the split-thickness skin graft (STSG) donor site dressing has been controversial until now. Our study here aimed to assess patient comfort and wound-healing efficacy with the application of thin split-thickness grafting on STSG donor sites.

Detailed Description

Background：Split-thickness skin grafting remains fundamental treatment of patients with deep burns and other traumatic injuries. However, the split-thickness skin graft (STSG) donor site dressing has been controversial until now. Our study here aimed to assess patient comfort and wound-healing efficacy with the application of thin split-thickness grafting on STSG donor sites.

Methods: 192 consecutive patients undergoing split-thickness skin grafting were included in the study and the participants were randomly divided into three groups: Group A was regrafted with thin STSG, while, Group B and Group C were covered with the occlusive hydrocellular dressing and paraffin gauze, respectively. The three groups were compared regarding to the time of epithelialization, pain sensed by the patients and the scar formation.

Study Timeline

• Study Start: 2002-01
• Primary Completion: 2010-12
• Study Completion: 2013-03
• Study First Submitted: 2013-09-12
• Status Verified: 2013-10
• Study First Submitted QC: 2013-10-27
• Last Update Submitted: 2013-10-27
• Study First Posted: 2013-11-01
• Last Update Posted: 2013-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 192

Inclusion Criteria

• patients who continuously received an STSG from January 2002 to December 2010 in Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University

Exclusion Criteria

• The patients who were significant psychiatric, hypersensitive to silver, and not be followed up were excluded

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
the control group B	covered with the occlusive hydrocellular dressing	The group B covered with the occlusive hydrocellular dressing (Allevyn Adhesive, Smith \& Nephew)
the control group C	covered with paraffin gauze	Group C were covered with paraffin gauze
the treatment group A	regrafted with thin split-thickness skin graft	The people in treatment group were regrafted with thin split-thickness skin graft

Primary Outcome Measures

Name	Time	Method
The time of epithelialization	up to 4 weeks	The time of epithelialization was observed every 3 days

Secondary Outcome Measures

Name	Time	Method
Pain sensed by the patients	up to 6 months	Pain sensed by the patients was assessed by Wong-Baker FACES Pain Rating Scale on day 2 and 5 after surgery