Assessment of lactic acidosis associated with Metformin usage

Phase 3

• Conditions: I25.1; actic acidosis.; Atherosclerotic heart disease

• Registration Number: IRCT20200201046329N1
• Lead Sponsor: Alborz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 18 May 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Patient with type 2 diabetes who has undergone coronary angiography
The GFR before angiography is equal to or greater than 60 ml per minute
Patient with diabetes with a history of metformin usage
Patient's Ejection Fraction is equal to or greater than 45%
Patient's systolic blood pressure is equal to or greater than 90 mm Hg
Serum creatinine levels before angiography are less than 1.49 mg in males and less than 1.40 mg / ml in females
The patient's plasma pH should be 7.45-7.35 before angiography

Exclusion Criteria

Critical physical condition requires immediate intervention
Failure to perform PH or creatinine sampling and lactate levels after angiography
Sepsis and other conditions that cause lactic acidosis
Discontinuation of metformin usage by the patient
Diarrhea, vomiting, and other conditions that predispose the patient to dehydration
Increase serum creatinine by more than 1.5 mg / d

Study & Design

• Study Type: interventional
• Study Design: Not specified