PREEMPTIVE ANALGESIA USING LOW DOSE INTRAVENOUS KETAMINE FOR POST OPERATIVE PAIN IN PATIENTS UNDERGOING ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 190
- 试验地点
- 1
- 主要终点
- To evaluate the efficacy of preemptive use of small dose intravenous ketamine on post operative pain using Numeric Rating Scale Score on patients undergoing elective laparoscopic cholecystectomy
研究概览
简要总结
The most important factor related to patient discomfort after surgery is pain. The concept of Pre-emptive analgesia is to reduce central sensitization that arises from noxious input during the perioperative period and also the magnitude and duration of post operative pain.
Pre-emptive analgesia gives rise to a subsiding pain pattern, a decrease in analgesic requirement and a decline in morbidity, promoting wellness and shortening the length of hospital stay.
Laparoscopic cholesystectomy as a minimally invasive surgery has become extremely common in recent decades. Despite the fact that Laparoscopic cholecystectomy is associated with less pain and disability , nonetheless as many as 76.7% patients experience moderate to severe pain ( NRS 4-10) within first 24 hours
Although many drugs have demonstrated the evidence of preemptive analgesic benefit. Ketamine , an NMDA receptor antagonist have received greatest attention because NMDA receptors have effectiveness to intercept intra as well as post operative pain and also had role in central sensitization and neural modulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Double
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Age : 18-60years.
- •2.ASA grade 1 and
- •3.Patient posted for elective laparoscopic cholecystectomy.
- •4.Patients giving consent to participate in the study.
排除标准
- •Patient not willing to give informed and written consent.
- •BMI more than
- •Surgery converted to open cholecystectomy.
- •Chronic pain syndrome.
- •Drugs , opiods , or any substance abuse.
- •History of allergy to ketamine.
- •Raised intra-cranial pressure.
- •Known case of hypertension , hyperthyroidism , psychiatric disorder.
- •History of seizure or taking anticonvulsant medication.
结局指标
主要结局
To evaluate the efficacy of preemptive use of small dose intravenous ketamine on post operative pain using Numeric Rating Scale Score on patients undergoing elective laparoscopic cholecystectomy
时间窗: To evaluate the efficacy of preemptive use of small dose intravenous ketamine on post operative pain using Numeric Rating Scale Score at time 0(immediately after arousal), 6,12 and 24 hours on patients undergoing elective laparoscopic cholecystectomy
次要结局
- 1. To evaluate time interval for first request of analgesia.(2.To evaluate post operative total opioid consumption in first 24 hours.)
研究者
Dr Nazia Akhtar Barbhuiya
Gauhati Medical College And Hospital , Guwahati