JPRN-UMIN000012413RecruitingPhase 2
A phase II trial of induction CDDP plus TS-1 with concurrent radiotherapy followed by surgical resection in patients with pathologically confirmed stage IIIA-N2 squamous-cell non-small cell lung cancer - Personalized Induction Therapy Clinical Trial-2(PIT-2)
Advanced Clinical Trial chest surgery Group (ACTG)0 sites80 target enrollmentStarted: November 27, 2013Last updated:
Trial Snapshot
- Phase
- Phase 2
- Status
- Recruiting
- Sponsor
- Enrollment
- 80
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 20years-old to 75years-old (—)
- Sex
- All
Inclusion Criteria
- Not provided
Exclusion Criteria
- •(1) Uncontrollable systemic disease (hyper tension, diabetes mellitus etc.) (2) Current history of hemosputum or hemoptysis (3) Evidence of bleeding diathesis or coagulopathy (4) Cavity in lung tumor or great vessel involvement (5) Current or previous (within the last 1 year) history of cerebrovascular disease (6) Traumatic fracture of un recovery (7) History of active infection (8) Hepatitis Bc antibody or hepatitis Bs antigen positive (9) Therapeutic anticoagulation; regular use of aspirin (>325 mg/day) (10) Severe GI disease (11) Current or previous (within the last 1 year) history of GI perforation or diverticultis (12) History of severe heart disease (13) Severe diarrhea (14) Severe drug allergy (15) Investigational new drug or the unapproved drug is administered (16) Interstitial pneumonia or pulmonary fibrosis detectable on chest Xp (17) History of active double cancer (18) History of pregnancy or lactation (19) Any other medical condition that makes the patient unsuitable for inclusion in the study according to the opinion of the investigator
Investigators
Similar Trials
Active, not recruiting
Phase 2
PIT-2Primary lung cancerMediastinal lymph node metastasis, Squamous cell carcinomaJPRN-jRCTs031180403Suzuki Kenji45
Completed
Phase 2
A phase II trial of induction CDDP plus TS-1 with concurrent radiotherapy followed by surgical resection in patients with resectable stage IIIA-N2 non-small cell lung cancerJPRN-UMIN000018138Gunma University Hospital30
Completed
Phase 1
A Phase I/II study of combination of TS-1, CDDP plus PTX in patients with advanced/recurrent gastric cancer (OGSG 0703)JPRN-UMIN000002183OGSG40
Completed
Phase 2
A randomized phase II trial of induction CDDP +PEM +BEV versus CDDP + PEM with concurrent radiotherapy followed by surgical resection in patients with pathologically confirmed stage IIIA-N2 non-squamous- cell non-small cell lung cancerStage IIIA-N2 Non-squamous, Non-small cell lung cancerJPRN-UMIN000011941Advanced Clinical Trial chest surgery Group (ACTG)80
Recruiting
Not Applicable
PhaseI/II study of TS-1+CDDP in combination with Radiotherapy with unresectable and locally advanced for biliary tract cancerBiliary tract cancerJPRN-UMIN000007473Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University25